呼吸窘迫综合征早产儿血清 Ｃｌａｒａ 细胞分泌蛋白水平变化及意义

Objective To investigate the changes and clinical significance of serum Clara cell secretory protein (CCSP) in premature infants with respiratory distress syndrome (RDS). Methods A total of 63 preterm infants horn in Zhuhai People's Hospital from June 2013 to June 2015 were selected as the study objects, including 30 preterm infants with RDS in the observation group and 33 preterm infants without RDS in the control group. The serum CCSP level of preterm infants in the two groups was detected by double-antibody sandwich enzyme-linked immunosorbent assay at 2 hours and 3,7,14 days after birth. Results In the observation group,the serum CCSP level of premature infants gradually increased from 2 hours to 7 days after birth, reached the peak value on the 7 ' day, and remained at a relatively stable level from the 7 ' to the 14th day. In the control group, the serum CCSP level of premature infants gradually increased from 2 hours to 3 days after birth, reached the peak value on the 3 day,then began to decrease and maintained at a relatively stable level from the 7 ' to the 14 day. The serum CCSP level of premature infants at 2 hours after birth was significantly lower than that on the 3",7 ' and 14 day in the observation group (t= —2.805, -3.898, — 3. 580;/5 <0. 05). There was no significant difference in serum CCSP level of premature infants in the observation group on the 3'",7'" and 14th day after birth (t = -1.092, -0. 775,0. 318;P > 0. 05). The serum CCSP level of premature infants on the 3rd day after birth was significantly higher than that at 2 hours and 7,14 days after birth in the control group (t = 3. 834,2. 627,2. 818;P < 0. 05). There was no significant difference in serum CCSP levels of premature infants at 2 hours and 7,14 days after birth in the control group (t = - 1. 207,1. 016,0. 191;P > 0. 05). The serum CCSP level of premature infants in the observation group was significantly lower than that in the control group at 2 hours and three days after birth (t = 2. 878,2. 658; P < 0. 05). There was no significant difference in serum CCSP level of premature infants between the two groups on the 7L and 14' day after birth (t = 0. 776,1. 146;P > 0. 05). Conclusion The level of serum CCSP in RDS preterm infants is decreased. The level of serum CCSP has a certain value in predicting the occurrence, development and outcome of RDS in preterm infants,it can be used as a biomarker of RDS in preterm infants.