虫草素抗肿瘤药理作用及其机制的研究进展

Translated title of the contribution: Progress on anti-tumor pharmacological effects and mechanism of cordycepin

Xi Cai, Chao Shang, Lirong Meng

Research output: Contribution to journalArticlepeer-review

Abstract

Cordycepin is one of the main active constituent of the Chinese traditional medicine Cordyceps sinensis. Multiple biological activities of it have been found in past researches, such as anti-tumor, antiviral, and immunomodulation. In recent years, its anti-tumor mechanism has increasingly become a research hotspot, and it has been studied in various tumors such as lung cancer, liver cancer, and breast cancer. It was found that cordycepin inhibits tumor cell proliferation, migration and invasion through AMPK, PI3K/Akt, NF-κB and other signal pathways, and promotes tumor cell apoptosis. The molecular mechanism of cordycepin in different tumors, and the problems in its application and the countermeasures are reviewed, in order to provide a reference for research and development of new anticancer drugs.

Translated title of the contributionProgress on anti-tumor pharmacological effects and mechanism of cordycepin
Original languageChinese (Traditional)
Pages (from-to)1548-1554
Number of pages7
JournalDrug Evaluation Research
Volume44
Issue number7
DOIs
Publication statusPublished - Jul 2021

Keywords

  • 3'-deoxyadenosine
  • AMPK
  • Cordycepin
  • NF-κB
  • PI3K/Akt
  • antitumor

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