虫草素抗肿瘤药理作用及其机制的研究进展

Xi Cai; Chao Shang; Lirong Meng

doi:10.7501/j.issn.1674-6376.2021.07.028

虫草素抗肿瘤药理作用及其机制的研究进展

Translated title of the contribution: Progress on anti-tumor pharmacological effects and mechanism of cordycepin

Xi Cai
, Chao Shang
, Lirong Meng

Faculty of Health Sciences and Sports

China Medical University

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Cordycepin is one of the main active constituent of the Chinese traditional medicine Cordyceps sinensis. Multiple biological activities of it have been found in past researches, such as anti-tumor, antiviral, and immunomodulation. In recent years, its anti-tumor mechanism has increasingly become a research hotspot, and it has been studied in various tumors such as lung cancer, liver cancer, and breast cancer. It was found that cordycepin inhibits tumor cell proliferation, migration and invasion through AMPK, PI3K/Akt, NF-κB and other signal pathways, and promotes tumor cell apoptosis. The molecular mechanism of cordycepin in different tumors, and the problems in its application and the countermeasures are reviewed, in order to provide a reference for research and development of new anticancer drugs.

Translated title of the contribution	Progress on anti-tumor pharmacological effects and mechanism of cordycepin
Original language	Chinese (Traditional)
Pages (from-to)	1548-1554
Number of pages	7
Journal	Drug Evaluation Research
Volume	44
Issue number	7
DOIs	https://doi.org/10.7501/j.issn.1674-6376.2021.07.028
Publication status	Published - Jul 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

3'-deoxyadenosine
AMPK
Cordycepin
NF-κB
PI3K/Akt
antitumor

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10.7501/j.issn.1674-6376.2021.07.028

Cite this

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abstract = "Cordycepin is one of the main active constituent of the Chinese traditional medicine Cordyceps sinensis. Multiple biological activities of it have been found in past researches, such as anti-tumor, antiviral, and immunomodulation. In recent years, its anti-tumor mechanism has increasingly become a research hotspot, and it has been studied in various tumors such as lung cancer, liver cancer, and breast cancer. It was found that cordycepin inhibits tumor cell proliferation, migration and invasion through AMPK, PI3K/Akt, NF-κB and other signal pathways, and promotes tumor cell apoptosis. The molecular mechanism of cordycepin in different tumors, and the problems in its application and the countermeasures are reviewed, in order to provide a reference for research and development of new anticancer drugs.",

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author = "Xi Cai and Chao Shang and Lirong Meng",

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N2 - Cordycepin is one of the main active constituent of the Chinese traditional medicine Cordyceps sinensis. Multiple biological activities of it have been found in past researches, such as anti-tumor, antiviral, and immunomodulation. In recent years, its anti-tumor mechanism has increasingly become a research hotspot, and it has been studied in various tumors such as lung cancer, liver cancer, and breast cancer. It was found that cordycepin inhibits tumor cell proliferation, migration and invasion through AMPK, PI3K/Akt, NF-κB and other signal pathways, and promotes tumor cell apoptosis. The molecular mechanism of cordycepin in different tumors, and the problems in its application and the countermeasures are reviewed, in order to provide a reference for research and development of new anticancer drugs.

AB - Cordycepin is one of the main active constituent of the Chinese traditional medicine Cordyceps sinensis. Multiple biological activities of it have been found in past researches, such as anti-tumor, antiviral, and immunomodulation. In recent years, its anti-tumor mechanism has increasingly become a research hotspot, and it has been studied in various tumors such as lung cancer, liver cancer, and breast cancer. It was found that cordycepin inhibits tumor cell proliferation, migration and invasion through AMPK, PI3K/Akt, NF-κB and other signal pathways, and promotes tumor cell apoptosis. The molecular mechanism of cordycepin in different tumors, and the problems in its application and the countermeasures are reviewed, in order to provide a reference for research and development of new anticancer drugs.

KW - 3'-deoxyadenosine

KW - AMPK

KW - Cordycepin

KW - NF-κB

KW - PI3K/Akt

KW - antitumor

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DO - 10.7501/j.issn.1674-6376.2021.07.028

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虫草素抗肿瘤药理作用及其机制的研究进展

Abstract

UN SDGs

Keywords

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