2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6

Hongliang Duan; Jin Zheng; Qinglin Lai; Zheng Liu; Guanghui Tian; Zhen Wang; Jianfeng Li; Jingshan Shen

doi:10.1016/j.bmcl.2009.03.125

2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6

Hongliang Duan, Jin Zheng, Qinglin Lai, Zheng Liu, Guanghui Tian, Zhen Wang, Jianfeng Li, Jingshan Shen

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

In our efforts to minimize the side effects associated with low selectivity against the other PDE isozymes, a novel class of 2-phenylquinazolin-4(3H)-one derivatives were designed and prepared as potent PDE5 inhibitors with high selectivity against PDE6. The syntheses and SAR studies of such molecules were reported.

Original language	English
Pages (from-to)	2777-2779
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	10
DOIs	https://doi.org/10.1016/j.bmcl.2009.03.125
Publication status	Published - 15 May 2009
Externally published	Yes

Keywords

2-Phenylquinazolin-4(3H)-one
Erectile dysfunction
PDE5 Inhibitor
Selectivity versus PDE6
Sildenafil

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10.1016/j.bmcl.2009.03.125

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abstract = "In our efforts to minimize the side effects associated with low selectivity against the other PDE isozymes, a novel class of 2-phenylquinazolin-4(3H)-one derivatives were designed and prepared as potent PDE5 inhibitors with high selectivity against PDE6. The syntheses and SAR studies of such molecules were reported.",

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language = "English",

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AU - Duan, Hongliang

AU - Zheng, Jin

AU - Lai, Qinglin

AU - Liu, Zheng

AU - Tian, Guanghui

AU - Wang, Zhen

AU - Li, Jianfeng

AU - Shen, Jingshan

PY - 2009/5/15

Y1 - 2009/5/15

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AB - In our efforts to minimize the side effects associated with low selectivity against the other PDE isozymes, a novel class of 2-phenylquinazolin-4(3H)-one derivatives were designed and prepared as potent PDE5 inhibitors with high selectivity against PDE6. The syntheses and SAR studies of such molecules were reported.

KW - 2-Phenylquinazolin-4(3H)-one

KW - Erectile dysfunction

KW - PDE5 Inhibitor

KW - Selectivity versus PDE6

KW - Sildenafil

UR - http://www.scopus.com/inward/record.url?scp=65449165278&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2009.03.125

DO - 10.1016/j.bmcl.2009.03.125

M3 - Article

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AN - SCOPUS:65449165278

SN - 0960-894X

VL - 19

SP - 2777

EP - 2779

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 10

ER -

2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6

Abstract

Keywords

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