A cross-sectional study of human papillomavirus genotype distribution and integration status in penile cancer among Chinese population

Bin Lang; Dirong Dong; Tong Zhao; Ruolei Zhong; Huimin Qin; Chen Cao; Yuyan Wang; Ting Liu; Wenjia Liang; Xun Tian; Yongji Yan; Zheng Hu

doi:10.1016/j.virol.2023.04.013

A cross-sectional study of human papillomavirus genotype distribution and integration status in penile cancer among Chinese population

Bin Lang, Dirong Dong, Tong Zhao, Ruolei Zhong, Huimin Qin, Chen Cao, Yuyan Wang, Ting Liu, Wenjia Liang, Xun Tian, Yongji Yan, Zheng Hu

Peking University Health Science Center - Macao Polytechnic University Nursing Academy

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Human papillomavirus (HPV) has been recognized as an important risk factor in penile cancer. This study aimed to investigate the HPV subtypes and integration status in Chinese patients. Samples were collected from 103 penile cancer patients aged 24–90 years between 2013 and 2019. We found that HPV infection rate was 72.8%, with 28.0% integration. The aging patients were more susceptible to HPV (p = 0.009). HPV16 was the most frequent subtype observed (52/75) and exhibited the highest frequency of integration events, with 11 out of 30 single infection cases showing integration positive. The HPV integrations sites in the viral genome were not randomly distributed, the breakpoints were enriched in the E1 gene (p = 0.006) but relatively scarce in L1, E6 and E7. Our research might provide some clues how HPV leads to the progression of penile cancer.

Original language	English
Pages (from-to)	53-57
Number of pages	5
Journal	Virology
Volume	584
DOIs	https://doi.org/10.1016/j.virol.2023.04.013
Publication status	Published - Jul 2023

Keywords

Chinese population
Human papillomavirus
Human papillomavirus distribution
Human papillomavirus integration
Human papillomavirus prevalence
Penile cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.virol.2023.04.013

Cite this

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title = "A cross-sectional study of human papillomavirus genotype distribution and integration status in penile cancer among Chinese population",

abstract = "Human papillomavirus (HPV) has been recognized as an important risk factor in penile cancer. This study aimed to investigate the HPV subtypes and integration status in Chinese patients. Samples were collected from 103 penile cancer patients aged 24–90 years between 2013 and 2019. We found that HPV infection rate was 72.8%, with 28.0% integration. The aging patients were more susceptible to HPV (p = 0.009). HPV16 was the most frequent subtype observed (52/75) and exhibited the highest frequency of integration events, with 11 out of 30 single infection cases showing integration positive. The HPV integrations sites in the viral genome were not randomly distributed, the breakpoints were enriched in the E1 gene (p = 0.006) but relatively scarce in L1, E6 and E7. Our research might provide some clues how HPV leads to the progression of penile cancer.",

keywords = "Chinese population, Human papillomavirus, Human papillomavirus distribution, Human papillomavirus integration, Human papillomavirus prevalence, Penile cancer",

author = "Bin Lang and Dirong Dong and Tong Zhao and Ruolei Zhong and Huimin Qin and Chen Cao and Yuyan Wang and Ting Liu and Wenjia Liang and Xun Tian and Yongji Yan and Zheng Hu",

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year = "2023",

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doi = "10.1016/j.virol.2023.04.013",

language = "English",

volume = "584",

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T1 - A cross-sectional study of human papillomavirus genotype distribution and integration status in penile cancer among Chinese population

AU - Lang, Bin

AU - Dong, Dirong

AU - Zhao, Tong

AU - Zhong, Ruolei

AU - Qin, Huimin

AU - Cao, Chen

AU - Wang, Yuyan

AU - Liu, Ting

AU - Liang, Wenjia

AU - Tian, Xun

AU - Yan, Yongji

AU - Hu, Zheng

PY - 2023/7

Y1 - 2023/7

N2 - Human papillomavirus (HPV) has been recognized as an important risk factor in penile cancer. This study aimed to investigate the HPV subtypes and integration status in Chinese patients. Samples were collected from 103 penile cancer patients aged 24–90 years between 2013 and 2019. We found that HPV infection rate was 72.8%, with 28.0% integration. The aging patients were more susceptible to HPV (p = 0.009). HPV16 was the most frequent subtype observed (52/75) and exhibited the highest frequency of integration events, with 11 out of 30 single infection cases showing integration positive. The HPV integrations sites in the viral genome were not randomly distributed, the breakpoints were enriched in the E1 gene (p = 0.006) but relatively scarce in L1, E6 and E7. Our research might provide some clues how HPV leads to the progression of penile cancer.

AB - Human papillomavirus (HPV) has been recognized as an important risk factor in penile cancer. This study aimed to investigate the HPV subtypes and integration status in Chinese patients. Samples were collected from 103 penile cancer patients aged 24–90 years between 2013 and 2019. We found that HPV infection rate was 72.8%, with 28.0% integration. The aging patients were more susceptible to HPV (p = 0.009). HPV16 was the most frequent subtype observed (52/75) and exhibited the highest frequency of integration events, with 11 out of 30 single infection cases showing integration positive. The HPV integrations sites in the viral genome were not randomly distributed, the breakpoints were enriched in the E1 gene (p = 0.006) but relatively scarce in L1, E6 and E7. Our research might provide some clues how HPV leads to the progression of penile cancer.

KW - Chinese population

KW - Human papillomavirus

KW - Human papillomavirus distribution

KW - Human papillomavirus integration

KW - Human papillomavirus prevalence

KW - Penile cancer

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U2 - 10.1016/j.virol.2023.04.013

DO - 10.1016/j.virol.2023.04.013

M3 - Article

C2 - 37244055

AN - SCOPUS:85159901520

SN - 0042-6822

VL - 584

SP - 53

EP - 57

JO - Virology

JF - Virology

ER -

A cross-sectional study of human papillomavirus genotype distribution and integration status in penile cancer among Chinese population

Abstract

Keywords

UN SDGs

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Peking University Health Science Center Reports Findings in Penile Cancer (A cross-sectional study of human papillomavirus genotype distribution and integration status in penile cancer among Chinese population)

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A cross-sectional study of human papillomavirus genotype distribution and integration status in penile cancer among Chinese population

Abstract

Keywords

UN SDGs

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Peking University Health Science Center Reports Findings in Penile Cancer (A cross-sectional study of human papillomavirus genotype distribution and integration status in penile cancer among Chinese population)

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