A cross-sectional study of human papillomavirus genotype distribution and integration status in penile cancer among Chinese population

Bin Lang, Dirong Dong, Tong Zhao, Ruolei Zhong, Huimin Qin, Chen Cao, Yuyan Wang, Ting Liu, Wenjia Liang, Xun Tian, Yongji Yan, Zheng Hu

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Human papillomavirus (HPV) has been recognized as an important risk factor in penile cancer. This study aimed to investigate the HPV subtypes and integration status in Chinese patients. Samples were collected from 103 penile cancer patients aged 24–90 years between 2013 and 2019. We found that HPV infection rate was 72.8%, with 28.0% integration. The aging patients were more susceptible to HPV (p = 0.009). HPV16 was the most frequent subtype observed (52/75) and exhibited the highest frequency of integration events, with 11 out of 30 single infection cases showing integration positive. The HPV integrations sites in the viral genome were not randomly distributed, the breakpoints were enriched in the E1 gene (p = 0.006) but relatively scarce in L1, E6 and E7. Our research might provide some clues how HPV leads to the progression of penile cancer.

Original languageEnglish
Pages (from-to)53-57
Number of pages5
JournalVirology
Volume584
DOIs
Publication statusPublished - Jul 2023

Keywords

  • Chinese population
  • Human papillomavirus
  • Human papillomavirus distribution
  • Human papillomavirus integration
  • Human papillomavirus prevalence
  • Penile cancer

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