A unimolecular channel formed by dual helical peptide modified pillar[5]arene: Correlating transmembrane transport properties with antimicrobial activity and haemolytic toxicity

Pengyang Xin, Yonghui Sun, Huiyuan Kong, Yaodong Wang, Si Tan, Jingjing Guo, Tao Jiang, Wenpei Dong, Chang Po Chen

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Five unimolecular channels with different lengths are presented. The varying length of these channels has significant impact on their transmembrane transport properties, which are directly correlated with their antimicrobial activity and inversely correlated with their haemolytic toxicity. By further structural optimization, these new channels could reach high antimicrobial activity and very low haemolytic toxicity, with the potential to serve as systemic antibiotics.

Original languageEnglish
Pages (from-to)11492-11495
Number of pages4
JournalChemical Communications
Volume53
Issue number83
DOIs
Publication statusPublished - 2017
Externally publishedYes

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