A vanillin derivative suppresses the growth of HT29 cells through the Wnt/β-catenin signaling pathway

Wantong Ma; Xue Li; Peng Song; Qianqian Zhang; Zhengrong Wu; Jianhui Wang; Xiaofeng Li; Ruixiang Xu; Wenbin Zhao; Yuheng Liu; Huanxiang Liu; Xiaojun Yao; Xiaoliang Tang; Peng Chen

doi:10.1016/j.ejphar.2019.01.047

A vanillin derivative suppresses the growth of HT29 cells through the Wnt/β-catenin signaling pathway

Wantong Ma
, Xue Li
, Peng Song
, Qianqian Zhang
, Zhengrong Wu
, Jianhui Wang
, Xiaofeng Li
, Ruixiang Xu
, Wenbin Zhao
, Yuheng Liu
, Huanxiang Liu
, Xiaojun Yao
, Xiaoliang Tang
, Peng Chen

Lanzhou University
Yale University
Macau University of Science and Technology

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Colorectal cancer (CRC) is a common malignancy and the leading cause of cancer death worldwide. According to previous studies, vanillin possesses pharmacological and anticancer activities. In this work, we have modified the structure of vanillin to obtain a vanillin derivative called 4-(1H-imidazo [4,5-f][1,10]-phenanthrolin-2-yl)-2-methoxyphenol (IPM711), which has improved anticancer activity. The present study is intended to explore the anti-colorectal cancer activity of IPM711 in HT29 and HCT116 cells. The results of this study suggest that IPM711 can inhibit the growth, invasion and migration of HT29 and HCT116 cells. Western blot and molecular docking showed that IPM711 could bind to a Wnt/β-catenin signaling receptor to inhibit cell growth, invasion and migration in HT29 cells. Based on these results, IPM711 is a promising anticancer drug candidate for human colorectal cancer therapy.

Original language	English
Pages (from-to)	43-49
Number of pages	7
Journal	European Journal of Pharmacology
Volume	849
DOIs	https://doi.org/10.1016/j.ejphar.2019.01.047
Publication status	Published - 15 Apr 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Colorectal cancer
Invasion
Migration
Vanillin derivative
Wnt/β-catenin

Access to Document

10.1016/j.ejphar.2019.01.047

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title = "A vanillin derivative suppresses the growth of HT29 cells through the Wnt/β-catenin signaling pathway",

abstract = "Colorectal cancer (CRC) is a common malignancy and the leading cause of cancer death worldwide. According to previous studies, vanillin possesses pharmacological and anticancer activities. In this work, we have modified the structure of vanillin to obtain a vanillin derivative called 4-(1H-imidazo [4,5-f][1,10]-phenanthrolin-2-yl)-2-methoxyphenol (IPM711), which has improved anticancer activity. The present study is intended to explore the anti-colorectal cancer activity of IPM711 in HT29 and HCT116 cells. The results of this study suggest that IPM711 can inhibit the growth, invasion and migration of HT29 and HCT116 cells. Western blot and molecular docking showed that IPM711 could bind to a Wnt/β-catenin signaling receptor to inhibit cell growth, invasion and migration in HT29 cells. Based on these results, IPM711 is a promising anticancer drug candidate for human colorectal cancer therapy.",

keywords = "Colorectal cancer, Invasion, Migration, Vanillin derivative, Wnt/β-catenin",

author = "Wantong Ma and Xue Li and Peng Song and Qianqian Zhang and Zhengrong Wu and Jianhui Wang and Xiaofeng Li and Ruixiang Xu and Wenbin Zhao and Yuheng Liu and Huanxiang Liu and Xiaojun Yao and Xiaoliang Tang and Peng Chen",

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year = "2019",

month = apr,

day = "15",

doi = "10.1016/j.ejphar.2019.01.047",

language = "English",

volume = "849",

pages = "43--49",

journal = "European Journal of Pharmacology",

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TY - JOUR

T1 - A vanillin derivative suppresses the growth of HT29 cells through the Wnt/β-catenin signaling pathway

AU - Ma, Wantong

AU - Li, Xue

AU - Song, Peng

AU - Zhang, Qianqian

AU - Wu, Zhengrong

AU - Wang, Jianhui

AU - Li, Xiaofeng

AU - Xu, Ruixiang

AU - Zhao, Wenbin

AU - Liu, Yuheng

AU - Liu, Huanxiang

AU - Yao, Xiaojun

AU - Tang, Xiaoliang

AU - Chen, Peng

PY - 2019/4/15

Y1 - 2019/4/15

N2 - Colorectal cancer (CRC) is a common malignancy and the leading cause of cancer death worldwide. According to previous studies, vanillin possesses pharmacological and anticancer activities. In this work, we have modified the structure of vanillin to obtain a vanillin derivative called 4-(1H-imidazo [4,5-f][1,10]-phenanthrolin-2-yl)-2-methoxyphenol (IPM711), which has improved anticancer activity. The present study is intended to explore the anti-colorectal cancer activity of IPM711 in HT29 and HCT116 cells. The results of this study suggest that IPM711 can inhibit the growth, invasion and migration of HT29 and HCT116 cells. Western blot and molecular docking showed that IPM711 could bind to a Wnt/β-catenin signaling receptor to inhibit cell growth, invasion and migration in HT29 cells. Based on these results, IPM711 is a promising anticancer drug candidate for human colorectal cancer therapy.

AB - Colorectal cancer (CRC) is a common malignancy and the leading cause of cancer death worldwide. According to previous studies, vanillin possesses pharmacological and anticancer activities. In this work, we have modified the structure of vanillin to obtain a vanillin derivative called 4-(1H-imidazo [4,5-f][1,10]-phenanthrolin-2-yl)-2-methoxyphenol (IPM711), which has improved anticancer activity. The present study is intended to explore the anti-colorectal cancer activity of IPM711 in HT29 and HCT116 cells. The results of this study suggest that IPM711 can inhibit the growth, invasion and migration of HT29 and HCT116 cells. Western blot and molecular docking showed that IPM711 could bind to a Wnt/β-catenin signaling receptor to inhibit cell growth, invasion and migration in HT29 cells. Based on these results, IPM711 is a promising anticancer drug candidate for human colorectal cancer therapy.

KW - Colorectal cancer

KW - Invasion

KW - Migration

KW - Vanillin derivative

KW - Wnt/β-catenin

UR - https://www.scopus.com/pages/publications/85061127903

U2 - 10.1016/j.ejphar.2019.01.047

DO - 10.1016/j.ejphar.2019.01.047

M3 - Article

C2 - 30707959

AN - SCOPUS:85061127903

SN - 0014-2999

VL - 849

SP - 43

EP - 49

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

ER -

A vanillin derivative suppresses the growth of HT29 cells through the Wnt/β-catenin signaling pathway

Abstract

UN SDGs

Keywords

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