Artificial K                         +                          Channels Formed by Pillararene-Cyclodextrin Hybrid Molecules: Tuning Cation Selectivity and Generating Membrane Potential

Pengyang Xin; Huiyuan Kong; Yonghui Sun; Lingyu Zhao; Haodong Fang; Haofeng Zhu; Tao Jiang; Jingjing Guo; Qian Zhang; Wenpei Dong; Chang Po Chen

doi:10.1002/anie.201813797

Artificial K ⁺ Channels Formed by Pillararene-Cyclodextrin Hybrid Molecules: Tuning Cation Selectivity and Generating Membrane Potential

Pengyang Xin, Huiyuan Kong, Yonghui Sun, Lingyu Zhao, Haodong Fang, Haofeng Zhu, Tao Jiang, Jingjing Guo, Qian Zhang, Wenpei Dong, Chang Po Chen

Henan Normal University

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

A class of artificial K ⁺ channels formed by pillararene-cyclodextrin hybrid molecules have been designed and synthesized. These channels efficiently inserted into lipid bilayers and displayed high selectivity for K ⁺ over Na ⁺ in fluorescence and electrophysiological experiments. The cation transport selectivity of the artificial channels is tunable by varying the length of the linkers between pillararene and cyclodexrin. The shortest channel showed specific transmembrane transport preference for K ⁺ over all alkali metal ions (selective sequence: K ⁺ > Cs ⁺ > Rb ⁺ > Na ⁺ > Li ⁺ ), and is rarely observed for artificial K ⁺ channels. The high selectivity of this artificial channel for K ⁺ over Na ⁺ ensures specific transmembrane translocation of K ⁺ , and generated stable membrane potential across lipid bilayers.

Original language	English
Pages (from-to)	2779-2784
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	58
Issue number	9
DOIs	https://doi.org/10.1002/anie.201813797
Publication status	Published - 25 Feb 2019
Externally published	Yes

Keywords

cyclodextrins
ion channels
lipids
pillar[5]arenes
potassium

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10.1002/anie.201813797

Cite this

Xin, P., Kong, H., Sun, Y., Zhao, L., Fang, H., Zhu, H., Jiang, T., Guo, J., Zhang, Q., Dong, W., & Chen, C. P. (2019). Artificial K ⁺ Channels Formed by Pillararene-Cyclodextrin Hybrid Molecules: Tuning Cation Selectivity and Generating Membrane Potential. Angewandte Chemie - International Edition, 58(9), 2779-2784. https://doi.org/10.1002/anie.201813797

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title = "Artificial K + Channels Formed by Pillararene-Cyclodextrin Hybrid Molecules: Tuning Cation Selectivity and Generating Membrane Potential",

abstract = " A class of artificial K + channels formed by pillararene-cyclodextrin hybrid molecules have been designed and synthesized. These channels efficiently inserted into lipid bilayers and displayed high selectivity for K + over Na + in fluorescence and electrophysiological experiments. The cation transport selectivity of the artificial channels is tunable by varying the length of the linkers between pillararene and cyclodexrin. The shortest channel showed specific transmembrane transport preference for K + over all alkali metal ions (selective sequence: K + > Cs + > Rb + > Na + > Li + ), and is rarely observed for artificial K + channels. The high selectivity of this artificial channel for K + over Na + ensures specific transmembrane translocation of K + , and generated stable membrane potential across lipid bilayers.",

keywords = "cyclodextrins, ion channels, lipids, pillar[5]arenes, potassium",

author = "Pengyang Xin and Huiyuan Kong and Yonghui Sun and Lingyu Zhao and Haodong Fang and Haofeng Zhu and Tao Jiang and Jingjing Guo and Qian Zhang and Wenpei Dong and Chen, {Chang Po}",

note = "Publisher Copyright: {\textcopyright} 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",

year = "2019",

month = feb,

day = "25",

doi = "10.1002/anie.201813797",

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Xin, P, Kong, H, Sun, Y, Zhao, L, Fang, H, Zhu, H, Jiang, T, Guo, J, Zhang, Q, Dong, W & Chen, CP 2019, 'Artificial K ⁺ Channels Formed by Pillararene-Cyclodextrin Hybrid Molecules: Tuning Cation Selectivity and Generating Membrane Potential', Angewandte Chemie - International Edition, vol. 58, no. 9, pp. 2779-2784. https://doi.org/10.1002/anie.201813797

Artificial K ⁺ Channels Formed by Pillararene-Cyclodextrin Hybrid Molecules: Tuning Cation Selectivity and Generating Membrane Potential. / Xin, Pengyang; Kong, Huiyuan; Sun, Yonghui et al.
In: Angewandte Chemie - International Edition, Vol. 58, No. 9, 25.02.2019, p. 2779-2784.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Artificial K + Channels Formed by Pillararene-Cyclodextrin Hybrid Molecules

T2 - Tuning Cation Selectivity and Generating Membrane Potential

AU - Xin, Pengyang

AU - Kong, Huiyuan

AU - Sun, Yonghui

AU - Zhao, Lingyu

AU - Fang, Haodong

AU - Zhu, Haofeng

AU - Jiang, Tao

AU - Guo, Jingjing

AU - Zhang, Qian

AU - Dong, Wenpei

AU - Chen, Chang Po

PY - 2019/2/25

Y1 - 2019/2/25

N2 - A class of artificial K + channels formed by pillararene-cyclodextrin hybrid molecules have been designed and synthesized. These channels efficiently inserted into lipid bilayers and displayed high selectivity for K + over Na + in fluorescence and electrophysiological experiments. The cation transport selectivity of the artificial channels is tunable by varying the length of the linkers between pillararene and cyclodexrin. The shortest channel showed specific transmembrane transport preference for K + over all alkali metal ions (selective sequence: K + > Cs + > Rb + > Na + > Li + ), and is rarely observed for artificial K + channels. The high selectivity of this artificial channel for K + over Na + ensures specific transmembrane translocation of K + , and generated stable membrane potential across lipid bilayers.

AB - A class of artificial K + channels formed by pillararene-cyclodextrin hybrid molecules have been designed and synthesized. These channels efficiently inserted into lipid bilayers and displayed high selectivity for K + over Na + in fluorescence and electrophysiological experiments. The cation transport selectivity of the artificial channels is tunable by varying the length of the linkers between pillararene and cyclodexrin. The shortest channel showed specific transmembrane transport preference for K + over all alkali metal ions (selective sequence: K + > Cs + > Rb + > Na + > Li + ), and is rarely observed for artificial K + channels. The high selectivity of this artificial channel for K + over Na + ensures specific transmembrane translocation of K + , and generated stable membrane potential across lipid bilayers.

KW - cyclodextrins

KW - ion channels

KW - lipids

KW - pillar[5]arenes

KW - potassium

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Artificial K ⁺ Channels Formed by Pillararene-Cyclodextrin Hybrid Molecules: Tuning Cation Selectivity and Generating Membrane Potential

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