Artificial K + Channels Formed by Pillararene-Cyclodextrin Hybrid Molecules: Tuning Cation Selectivity and Generating Membrane Potential

Pengyang Xin, Huiyuan Kong, Yonghui Sun, Lingyu Zhao, Haodong Fang, Haofeng Zhu, Tao Jiang, Jingjing Guo, Qian Zhang, Wenpei Dong, Chang Po Chen

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)

Abstract

A class of artificial K + channels formed by pillararene-cyclodextrin hybrid molecules have been designed and synthesized. These channels efficiently inserted into lipid bilayers and displayed high selectivity for K + over Na + in fluorescence and electrophysiological experiments. The cation transport selectivity of the artificial channels is tunable by varying the length of the linkers between pillararene and cyclodexrin. The shortest channel showed specific transmembrane transport preference for K + over all alkali metal ions (selective sequence: K + > Cs + > Rb + > Na + > Li + ), and is rarely observed for artificial K + channels. The high selectivity of this artificial channel for K + over Na + ensures specific transmembrane translocation of K + , and generated stable membrane potential across lipid bilayers.

Original languageEnglish
Pages (from-to)2779-2784
Number of pages6
JournalAngewandte Chemie - International Edition
Volume58
Issue number9
DOIs
Publication statusPublished - 25 Feb 2019
Externally publishedYes

Keywords

  • cyclodextrins
  • ion channels
  • lipids
  • pillar[5]arenes
  • potassium

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