Assessment of phytochemicals and herbal formula for the treatment of depression through metabolomics

Xu Wang, Guanyu Lu, Xuan Liu, Jinhui Li, Fei Zhao, Kefeng Li

Research output: Contribution to journalShort surveypeer-review

1 Citation (Scopus)


Depression is a widespread and persistent psychiatric disease. Due to various side effects and no cu-rative treatments of conventional antidepressant drugs, botanical medicines have attracted considerable attention as a complementary and alternative approach. The pathogenesis of depression is quite complicated and un-clear. Metabolomics is a promising new technique for the discovery of novel biomarkers for exploring the potential mechanisms of diverse diseases and assessing the therapeutic effects of drugs. In this article, we system-atically reviewed the study of botanical medicine for the treatment of depression using metabolomics over a period from 2010 to 2019. Additionally, we summarized the potential biomarkers and metabolic pathways associated with herbal medicine treatment for depression. Through a comprehensive evaluation of herbal medicine as novel antidepressants and understanding of their pharmacomechanisms, a new perspective on expanding the application of botanical medicines for the treatment of depression is provided.

Original languageEnglish
Pages (from-to)840-854
Number of pages15
JournalCurrent Pharmaceutical Design
Issue number6
Publication statusPublished - 2021
Externally publishedYes


  • Antidepressants
  • Assessment
  • Herbal formula
  • Metabolic biomarkers
  • Metabolomics
  • Phytochemicals


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