Associations between metabolic dysfunction-associated fatty liver disease and atherosclerotic cardiovascular disease

Wen Wen, Hua Fan, Shenghui Zhang, Siqi Hu, Chen Chen, Jiake Tang, Yao You, Chunyi Wang, Jie Li, Lin Luo, Yongran Cheng, Mengyun Zhou, Xuezhi Zhao, Tao Tan, Fangfang Xu, Xinyan Fu, Juan Chen, Peng Dong, Xingwei Zhang, Mingwei WangYan Feng

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Non-alcoholic fatty liver disease (NAFLD) is closely related to metabolic syndrome and remains a major global health burden. The increased prevalence of obesity and type 2 diabetes mellitus (T2DM) worldwide has contributed to the rising incidence of NAFLD. It is widely believed that atherosclerotic cardiovascular disease (ASCVD) is associated with NAFLD. In the past decade, the clinical implications of NAFLD have gone beyond liver-related morbidity and mortality, with a majority of patient deaths attributed to malignancy, coronary heart disease (CHD), and other cardiovascular (CVD) complications. To better define fatty liver disease associated with metabolic disorders, experts proposed a new term in 2020 - metabolic dysfunction associated with fatty liver disease (MAFLD). Along with this new designation, updated diagnostic criteria were introduced, resulting in some differentiation between NAFLD and MAFLD patient populations, although there is overlap. The aim of this review is to explore the relationship between MAFLD and ASCVD based on the new definitions and diagnostic criteria, while briefly discussing potential mechanisms underlying cardiovascular disease in patients with MAFLD.

Original languageEnglish
Pages (from-to)557-568
Number of pages12
JournalAmerican Journal of the Medical Sciences
Volume368
Issue number6
DOIs
Publication statusPublished - Dec 2024

Keywords

  • Atherosclerotic cardiovascular disease
  • Metabolic dysfunction-associated fatty liver disease
  • Metabolic dysfunction-associated steatotic liver disease
  • Non-alcoholic fatty liver disease

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