Caffeine as a photoprotective agent for diminishing phototoxicity

Tong Szeto Yim Tong Szeto, Henry Hy Tong

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Skin whitening with Chinese herbal medicine has been used in ancient Asia. However, phototoxicity of the active ingredient limits the application. The modified comet assay was used in the current study to detect DNA crosslinking induced by phototoxicity. Result showed that caffeine at 5 µmol/L was able to reduce 5-methoxypsoralen-induced phototoxicity with ultraviolet C (UVC) exposure.

Original languageEnglish
Pages (from-to)667-670
Number of pages4
JournalToxicology and Industrial Health
Issue number10
Publication statusPublished - Nov 2010


  • 5-MOP
  • Phototoxic
  • caffeine
  • comet assay
  • crosslink


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