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Discussions on the generalization of HybridSP on more equivalent benchmarks

  • Zhihao Wang
  • , Sheng Wang
  • , Jingjing Guo
  • , Yuguang Mu
  • , Xiangdong Liu
  • , Liangzhen Zheng
  • , Weifeng Li
  • Shandong University
  • Shanghai Zelixir Biotech Company Ltd.
  • Nanyang Technological University

Research output: Contribution to journalLetterpeer-review

Abstract

We thank the reviewers for their thoughtful comments and we have carefully addressed the concerns raised. In our response, we clarify key methodological aspects and provide additional analyses to improve the transparency and rigor of our work. Importantly, we further evaluate the model on more diverse and fair benchmarks beyond the original setting, demonstrating its robustness and generalization ability. These additions strengthen the overall conclusions and provide a more comprehensive assessment of HybridSP.

Original languageEnglish
JournalBriefings in Bioinformatics
Volume27
Issue number2
DOIs
Publication statusPublished - Mar 2026

Keywords

  • protein-ligand interaction
  • scoring function
  • statistical potential

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