DNA methylation subtypes dictate metastatic heterogeneity of osteosarcoma via distinct tumor-stromal interactions: Multi-omics profiling and decitabine validation

Medicine and Dentistry

• Decitabine 100%
• Multi-Omics 100%
• Stromal Tumor 100%
• Osteosarcoma 100%
• Osteosarcoma Cell 66%
• Cell Transdifferentiation 66%
• Lung Metastasis 33%
• Gene Co-Expression Network 33%
• Fibroblast 33%
• Myeloid Cell 33%
• RNA Sequence 33%
• Cell Interaction 33%
• Neutrophil 33%
• Epigenetic Mechanism 33%
• Epigenetic Therapy 33%

Immunology and Microbiology

• DNA Methylation 100%
• Cell Transdifferentiation 66%
• Osteosarcoma Cell 66%
• Epigenetic Mechanism 33%
• Cell Interaction 33%
• SLC11A1 33%
• CXCR4 33%
• Fibroblast 33%

Biochemistry, Genetics and Molecular Biology

• Transdifferentiation 66%
• Cell-Cell Interaction 33%
• Epigenetic Therapy 33%
• CXCR4 33%
• Demethylating Agent 33%
• SLC11A1 33%