Effects of Cordycepin, Gold Nanostar, and Their Combination on Endometrial Cancer Cells

The incidence rate of (EC) has increased significantly in the past 2 decades. The current chemotherapy for this disease can cause intolerable side effects. Recently, both cordycepin and gold nanostars have demonstrated the ability to inhibit the growth and differentiation of cancers. This study aimed to investigate the antiEC effects of cordycepin, gold nanostars (Au NS), and the combination of the two. The gold nanostars were made by seed-mediated reduction, and their morphology was confirmed by laser particle size analysis, spectrophotometry, and electron microscopy. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide cytotoxicity assays, clonogenic assays, and flow cytometry were employed to evaluate the inhibition rate, survival fraction, and apoptosis in HEC-1A cells under different concentrations of cordycepin, Au NS, and their combination. This study revealed that both cordycepin and Au NS with 808 nm light exposure could inhibit cell proliferation, cause cell apoptosis, and inhibit the clone ability of EC cells. This study supports further investigations into Au NS-cordycepin in the development of new treatments for EC.