Effects of spray-drying and choice of solid carriers on concentrations of labrasol® and transcutol® in solid self-microemulsifying drug delivery systems (SMEDDS)

Liang Li, Tao Yi, Christopher Wai Kei Lam

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

Solid self-microemulsifying drug delivery systems (SMEDDS) have been used increasingly for improving the bioavailability of hydrophobic drugs. Labrasol® and Transcutol® are used widely as surfactant and solubilizer in the formulation of solid SMEDDS. We investigated the effects of spray-drying and the use of different solid carriers on concentrations of Labrasol® and Transcutol® in solid SMEDDS with scutellarin as the formulated drug. Liquid and gas chromatography tandem mass spectrometry (LC-MS and GC-MS) methods were developed for measuring low concentrations of Labrasol® and Transcutol®. In the preparation of solid SMEDDS, lactose, hydroxypropylmethyl cellulose (HPMC) and microcrystalline cellulose (MCC) were used as solid carriers. Judging from the retention ratios of Labrasol® and Transcutol®, the droplet size of solid SMEDDS increased after spray-drying of liquid SMEDDS, and concentrations of these excipients decreased after the solidifying procedure. In such reduction, Lactose and HPMC were found to preserve Labrasol® and Transcutol® better than MCC during spray-drying, and the resultant droplet sizes were smaller than that of MCC. Labrasol® and Transcutol® showed good thermal stability at 60 °C degree for 10 days. It can be concluded that spray-drying could increase the droplet size of solid SMEDDS and decreased the concentration of Labrasol® and Transcutol® therein, while water-soluble solid carriers could preserve Labrasol® and Transcutol® better than insoluble carriers in the solid SMEDDS.

Original languageEnglish
Pages (from-to)545-560
Number of pages16
JournalMolecules
Volume18
Issue number1
DOIs
Publication statusPublished - Jan 2013
Externally publishedYes

Keywords

  • Excipients
  • LC/GC-MS
  • Solid SMEDDS
  • Solid carriers
  • Spray-drying

Fingerprint

Dive into the research topics of 'Effects of spray-drying and choice of solid carriers on concentrations of labrasol® and transcutol® in solid self-microemulsifying drug delivery systems (SMEDDS)'. Together they form a unique fingerprint.

Cite this