Efficient glycosylation with glycosyl ortho-allylbenzoates as donors

Haijing Liang, Lixia Ma, Changwei Li, Qiang Peng, Zhaoyan Wang, Zhan xin Zhang, Lan Yu, Huanxiang Liu, Fengli An, Weihua Xue

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Glycosylation reactions are significant as they provide access to model compounds that are useful for elucidating biochemical pathways. Herein, we describe the development of glycosyl ortho-alkynylbenzoates as novel, bench-top stable, and readily available glycosyl donors. Glycosylation is promoted by inexpensive trimethylsilyl triflate (TMSOTf) in combination with N-iodosuccinimide (NIS) under mild reaction conditions; hence, the novel glycosyl donors are promising reagents for the synthesis of glycosides.

Original languageEnglish
Pages (from-to)84-87
Number of pages4
JournalTetrahedron Letters
Issue number1
Publication statusPublished - 3 Jan 2019
Externally publishedYes


  • Glycosyl ortho-allylbenzoates
  • Glycosylation
  • Lactonisation
  • NIS


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