Abstract
Crystal engineering provides a rational approach to solving formulation, processing and product performance problems. This review discusses how the concept of crystal engineering can be judiciously utilized to manipulate the solid-state properties of drugs and excipients for successful pharmaceutical formulation and process development. Existing and emerging manufacturing as well as co-processing technologies being applied in the pharmaceutical industry are also presented together with selected examples of crystal form design, crystal form selection and crystal modifications for illustration purposes.
Original language | English |
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Pages (from-to) | 2855-2877 |
Number of pages | 23 |
Journal | Journal of Pharmaceutical Sciences |
Volume | 97 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 2008 |
Keywords
- Crystal engineering
- Crystallization
- Formulation
- Particle size
- Pharmaceutical manufacturing
- Polymorphism
- Preformulation
- Selection of salt forms