Engineering of pharmaceutical materials: An industrial perspective

Kwok Chow, Henry H.Y. Tong, Susan Lum, Albert H.L. Chow

Research output: Contribution to journalReview articlepeer-review

135 Citations (Scopus)

Abstract

Crystal engineering provides a rational approach to solving formulation, processing and product performance problems. This review discusses how the concept of crystal engineering can be judiciously utilized to manipulate the solid-state properties of drugs and excipients for successful pharmaceutical formulation and process development. Existing and emerging manufacturing as well as co-processing technologies being applied in the pharmaceutical industry are also presented together with selected examples of crystal form design, crystal form selection and crystal modifications for illustration purposes.

Original languageEnglish
Pages (from-to)2855-2877
Number of pages23
JournalJournal of Pharmaceutical Sciences
Volume97
Issue number8
DOIs
Publication statusPublished - Aug 2008

Keywords

  • Crystal engineering
  • Crystallization
  • Formulation
  • Particle size
  • Pharmaceutical manufacturing
  • Polymorphism
  • Preformulation
  • Selection of salt forms

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