Engineering of pharmaceutical materials: An industrial perspective

Kwok Chow, Henry H.Y. Tong, Susan Lum, Albert H.L. Chow

Research output: Contribution to journalReview articlepeer-review

135 Citations (Scopus)


Crystal engineering provides a rational approach to solving formulation, processing and product performance problems. This review discusses how the concept of crystal engineering can be judiciously utilized to manipulate the solid-state properties of drugs and excipients for successful pharmaceutical formulation and process development. Existing and emerging manufacturing as well as co-processing technologies being applied in the pharmaceutical industry are also presented together with selected examples of crystal form design, crystal form selection and crystal modifications for illustration purposes.

Original languageEnglish
Pages (from-to)2855-2877
Number of pages23
JournalJournal of Pharmaceutical Sciences
Issue number8
Publication statusPublished - Aug 2008


  • Crystal engineering
  • Crystallization
  • Formulation
  • Particle size
  • Pharmaceutical manufacturing
  • Polymorphism
  • Preformulation
  • Selection of salt forms


Dive into the research topics of 'Engineering of pharmaceutical materials: An industrial perspective'. Together they form a unique fingerprint.

Cite this