Engineering of pharmaceutical materials: An industrial perspective

Kwok Chow; Henry H.Y. Tong; Susan Lum; Albert H.L. Chow

doi:10.1002/jps.21212

Engineering of pharmaceutical materials: An industrial perspective

Kwok Chow
, Henry H.Y. Tong
, Susan Lum
, Albert H.L. Chow

Faculty of Health Sciences and Sports

Research output: Contribution to journal › Review article › peer-review

146 Citations (Scopus)

Abstract

Crystal engineering provides a rational approach to solving formulation, processing and product performance problems. This review discusses how the concept of crystal engineering can be judiciously utilized to manipulate the solid-state properties of drugs and excipients for successful pharmaceutical formulation and process development. Existing and emerging manufacturing as well as co-processing technologies being applied in the pharmaceutical industry are also presented together with selected examples of crystal form design, crystal form selection and crystal modifications for illustration purposes.

Original language	English
Pages (from-to)	2855-2877
Number of pages	23
Journal	Journal of Pharmaceutical Sciences
Volume	97
Issue number	8
DOIs	https://doi.org/10.1002/jps.21212
Publication status	Published - Aug 2008

Keywords

Crystal engineering
Crystallization
Formulation
Particle size
Pharmaceutical manufacturing
Polymorphism
Preformulation
Selection of salt forms

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10.1002/jps.21212

Cite this

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title = "Engineering of pharmaceutical materials: An industrial perspective",

abstract = "Crystal engineering provides a rational approach to solving formulation, processing and product performance problems. This review discusses how the concept of crystal engineering can be judiciously utilized to manipulate the solid-state properties of drugs and excipients for successful pharmaceutical formulation and process development. Existing and emerging manufacturing as well as co-processing technologies being applied in the pharmaceutical industry are also presented together with selected examples of crystal form design, crystal form selection and crystal modifications for illustration purposes.",

keywords = "Crystal engineering, Crystallization, Formulation, Particle size, Pharmaceutical manufacturing, Polymorphism, Preformulation, Selection of salt forms",

author = "Kwok Chow and Tong, \{Henry H.Y.\} and Susan Lum and Chow, \{Albert H.L.\}",

note = "Funding Information: This article is dedicated to the late Professor David J. W. Grant, an inspirational leader and an excellent mentor in the field of crystal engineering. Financial support from the Macao Polytechnic Institute (Project No. RP/ESS 10/2005) for Henry H. T. Tong is gratefully acknowledged. ",

year = "2008",

month = aug,

doi = "10.1002/jps.21212",

language = "English",

volume = "97",

pages = "2855--2877",

journal = "Journal of Pharmaceutical Sciences",

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T2 - An industrial perspective

AU - Chow, Kwok

AU - Tong, Henry H.Y.

AU - Lum, Susan

AU - Chow, Albert H.L.

N1 - Funding Information: This article is dedicated to the late Professor David J. W. Grant, an inspirational leader and an excellent mentor in the field of crystal engineering. Financial support from the Macao Polytechnic Institute (Project No. RP/ESS 10/2005) for Henry H. T. Tong is gratefully acknowledged.

PY - 2008/8

Y1 - 2008/8

N2 - Crystal engineering provides a rational approach to solving formulation, processing and product performance problems. This review discusses how the concept of crystal engineering can be judiciously utilized to manipulate the solid-state properties of drugs and excipients for successful pharmaceutical formulation and process development. Existing and emerging manufacturing as well as co-processing technologies being applied in the pharmaceutical industry are also presented together with selected examples of crystal form design, crystal form selection and crystal modifications for illustration purposes.

AB - Crystal engineering provides a rational approach to solving formulation, processing and product performance problems. This review discusses how the concept of crystal engineering can be judiciously utilized to manipulate the solid-state properties of drugs and excipients for successful pharmaceutical formulation and process development. Existing and emerging manufacturing as well as co-processing technologies being applied in the pharmaceutical industry are also presented together with selected examples of crystal form design, crystal form selection and crystal modifications for illustration purposes.

KW - Crystal engineering

KW - Crystallization

KW - Formulation

KW - Particle size

KW - Pharmaceutical manufacturing

KW - Polymorphism

KW - Preformulation

KW - Selection of salt forms

UR - https://www.scopus.com/pages/publications/52449119950

U2 - 10.1002/jps.21212

DO - 10.1002/jps.21212

M3 - Review article

C2 - 17943933

AN - SCOPUS:52449119950

SN - 0022-3549

VL - 97

SP - 2855

EP - 2877

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

IS - 8

ER -

Engineering of pharmaceutical materials: An industrial perspective

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Keywords

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