ERNet: Edge Regularization Network for Cerebral Vessel Segmentation in Digital Subtraction Angiography Images

Weijin Xu, Huihua Yang, Yinghuan Shi, Tao Tan, Wentao Liu, Xipeng Pan, Yiming Deng, Feng Gao, Ruisheng Su

Research output: Contribution to journalArticlepeer-review


Stroke is a leading cause of disability and fatality in the world, with ischemic stroke being the most common type. Digital Subtraction Angiography images, the gold standard in the operation process, can accurately show the contours and blood flow of cerebral vessels. The segmentation of cerebral vessels in DSA images can effectively help physicians assess the lesions. However, due to the disturbances in imaging parameters and changes in imaging scale, accurate cerebral vessel segmentation in DSA images is still a challenging task. In this paper, we propose a novel Edge Regularization Network (ERNet) to segment cerebral vessels in DSA images. Specifically, ERNet employs the erosion and dilation processes on the original binary vessel annotation to generate pseudo-ground truths of False Negative and False Positive, which serve as constraints to refine the coarse predictions based on their mapping relationship with the original vessels. In addition, we exploit a Hybrid Fusion Module based on convolution and transformers to extract local features and build long-range dependencies. Moreover, to support and advance the open research in the field of ischemic stroke, we introduce FPDSA, the first pixel-level semantic segmentation dataset for cerebral vessels. Extensive experiments on FPDSA illustrate the leading performance of our ERNet.

Original languageEnglish
Pages (from-to)1472-1483
Number of pages12
JournalIEEE Journal of Biomedical and Health Informatics
Issue number3
Publication statusPublished - 1 Mar 2024


  • Cerebral vessel segmentation
  • digital subtraction angiography
  • edge regularization
  • stroke


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