Evaluation of extemporaneous oral itraconazole suspensions by dissolution profiles mapping

Henry H.Y. Tong, Hokman Chan, Zhen Du, Ying Zheng

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The objective of this study was to evaluate by dissolution profiles mapping five extemporaneous oral itraconazole suspensions reported in literature. Dissolution profiles of the extemporaneous oral itraconazole preparations were mapped and correlated with their reported clinical data therein. Four out of five extemporaneous preparations had either too early or insufficient release of itraconazole during dissolution study, potentially limiting the in vivo oral bioavailability in patients. Dissolution profile in the remaining extemporaneous preparation was closely similar to that in commercial itraconazole capsules. Based on the reported clinical data and dissolution results in this study, the extemporaneous preparation proposed in a study by Ong and Fobes seems to be the most reasonable choice for our patients. Dissolution profile evaluation is an important quality-control parameter during the evaluation of extemporaneous preparations by pharmacists.

Original languageEnglish
Pages (from-to)342-345
Number of pages4
JournalInternational Journal of Pharmaceutical Compounding
Volume14
Issue number4
Publication statusPublished - Jul 2010

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