Exercise Training Increases Serum Cardiac Troponin T Independent of Left Ventricular Mass

Zhaowei Kong, Haifeng Zhang, Jinlei Nie, Li Wen, Qingde Shi, San Fan Ng, Chuanye Huang, Keith George

Research output: Contribution to journalArticlepeer-review


The purpose of this study was to determine whether exercise training mediated cardiac troponin T (cTnT) and whether this was associated with increases in left ventricular mass (LVM). Fifty-four sedentary obese women were randomised to high-intensity interval training (HIIT, repeated 4-min cycling at 90% V˙O 2maxinterspersed with 3-min rest), work-equivalent continuous aerobic training (CAT, continuous cycling at 60% V˙O 2max) or a control group (CON). Resting serum cTnT was assessed using a high-sensitivity assay before and after 12 weeks of training. LVM was determined from 2D echocardiography at the same timepoints. Both HIIT and CAT induced a similar elevation (median 3.07 to 3.76 ng.l -1, p< 0.05) in resting cTnT compared with pre-Training and the CON (3.49 to 3.45 ng.l -1, p> 0.05). LVM index in HIIT increased (62.2±7.8 to 73.1±14.1 g.m -2, p< 0.05), but not in CAT (66.1±9.7 to 67.6±9.6 g.m -2, p> 0.05) and CON (67.9±9.5 to 70.2±9.1 g.m -2, p> 0.05). Training-induced changes in resting cTnT did not correlate with changes in LVM index (r =-0.025, p =0.857). These findings suggest that twelve weeks of either HIIT or CAT increased resting cTnT, but the effects were independent of any changes in LVM in sedentary obese women.

Original languageEnglish
Pages (from-to)505-511
Number of pages7
JournalInternational Journal of Sports Medicine
Issue number6
Publication statusPublished - Jun 2022


  • aerobic training
  • cardiac biomarker
  • cardiovascular risk factor
  • high-intensity interval training


Dive into the research topics of 'Exercise Training Increases Serum Cardiac Troponin T Independent of Left Ventricular Mass'. Together they form a unique fingerprint.

Cite this