TY - JOUR
T1 - Interventions for suicidal and self-injurious related behaviors in adolescents with psychiatric disorders
T2 - a systematic review and meta-analysis
AU - Lu, Junjie
AU - Huang, Jun
AU - Gao, Wanting
AU - Wang, Zexin
AU - Yang, Nan
AU - Luo, Yingbin
AU - Guo, Junxin
AU - Pang, Weng Ian Phoenix
AU - Lok, Grace Ka In
AU - Rao, Wenwang
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2025/12
Y1 - 2025/12
N2 - As a leading cause of adolescent death, suicidal and self-injurious related behaviors (SSIRBs) is a devastating global health problem, particularly among patients with psychiatric disorders (PDs). Previous studies have shown that multiple interventions can alleviate symptoms and reduce risks. This review aimed to provide a systematic summary of interventions (i.e., medication, physical therapy, psychosocial therapy) for the treatment of SSIRBs among Chinese adolescents with PDs. From inception to September 17, 2023, twelve databases (PubMed, CINAHL, ScienceDirect, PsycINFO, EMBASE, Cochrane Library, Clinical Trial, Web of Science, CEPS, SinoMed, Wanfang and CNKI) were searched. We qualitatively and quantitatively synthesized the included studies. Standardized mean differences (SMDs), risk ratios and their 95% confidence intervals (CIs) used the Der Simonian and Laird random-effects model. Fifty-two studies covering 3709 eligible participants were included. Overall, the commonly used interventions targeting SSIRBs and negative feelings in PDs adolescents with SSIRBs included psychosocial therapy (e.g., cognitive behavioral therapy), medication (e.g., antidepressants), and physiotherapy (e.g., repetitive transcranial magnetic stimulation). Importantly, quetiapine fumarate in combination with sodium valproate (SV) had positive effects on reducing self-injury behaviors score [SMD: −2.466 (95% CI: −3.305, −1.628), I2 = 88.36%], depression [SMD: −1.587 (95% CI: −2.505, −0.670), I2 = 90.45%], anxiety [SMD: −1.925 (95% CI: −2.700, −1.150), I2 = 85.23%], impulsivity [SMD: −2.439 (95% CI: −2.748, −2.094), I2 = 0%], as well as its safety in comparison with SV alone. No significant difference of adverse reactions was found by low-dose QF (P > 0.05). This review systematically outlined the primary characteristics, safety and effectiveness of interventions for Chinese PDs adolescents with SSIRBs, which could serve as valuable evidence for guidelines aiming to formulate recommendations.
AB - As a leading cause of adolescent death, suicidal and self-injurious related behaviors (SSIRBs) is a devastating global health problem, particularly among patients with psychiatric disorders (PDs). Previous studies have shown that multiple interventions can alleviate symptoms and reduce risks. This review aimed to provide a systematic summary of interventions (i.e., medication, physical therapy, psychosocial therapy) for the treatment of SSIRBs among Chinese adolescents with PDs. From inception to September 17, 2023, twelve databases (PubMed, CINAHL, ScienceDirect, PsycINFO, EMBASE, Cochrane Library, Clinical Trial, Web of Science, CEPS, SinoMed, Wanfang and CNKI) were searched. We qualitatively and quantitatively synthesized the included studies. Standardized mean differences (SMDs), risk ratios and their 95% confidence intervals (CIs) used the Der Simonian and Laird random-effects model. Fifty-two studies covering 3709 eligible participants were included. Overall, the commonly used interventions targeting SSIRBs and negative feelings in PDs adolescents with SSIRBs included psychosocial therapy (e.g., cognitive behavioral therapy), medication (e.g., antidepressants), and physiotherapy (e.g., repetitive transcranial magnetic stimulation). Importantly, quetiapine fumarate in combination with sodium valproate (SV) had positive effects on reducing self-injury behaviors score [SMD: −2.466 (95% CI: −3.305, −1.628), I2 = 88.36%], depression [SMD: −1.587 (95% CI: −2.505, −0.670), I2 = 90.45%], anxiety [SMD: −1.925 (95% CI: −2.700, −1.150), I2 = 85.23%], impulsivity [SMD: −2.439 (95% CI: −2.748, −2.094), I2 = 0%], as well as its safety in comparison with SV alone. No significant difference of adverse reactions was found by low-dose QF (P > 0.05). This review systematically outlined the primary characteristics, safety and effectiveness of interventions for Chinese PDs adolescents with SSIRBs, which could serve as valuable evidence for guidelines aiming to formulate recommendations.
UR - http://www.scopus.com/inward/record.url?scp=86000070868&partnerID=8YFLogxK
U2 - 10.1038/s41398-025-03278-7
DO - 10.1038/s41398-025-03278-7
M3 - Review article
C2 - 40044640
AN - SCOPUS:86000070868
SN - 2158-3188
VL - 15
JO - Translational Psychiatry
JF - Translational Psychiatry
IS - 1
M1 - 73
ER -
