Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes

Peng Xiao; Wei Yan; Lu Gou; Ya Ni Zhong; Liangliang Kong; Chao Wu; Xin Wen; Yuan Yuan; Sheng Cao; Changxiu Qu; Xin Yang; Chuan Cheng Yang; Anjie Xia; Zhenquan Hu; Qianqian Zhang; Yong Hao He; Dao Lai Zhang; Chao Zhang; Gui Hua Hou; Huanxiang Liu; Lizhe Zhu; Ping Fu; Shengyong Yang; Daniel M. Rosenbaum; Jin Peng Sun; Yang Du; Lei Zhang; Xiao Yu; Zhenhua Shao

doi:10.1016/j.cell.2021.01.028

Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes

Peng Xiao
, Wei Yan
, Lu Gou
, Ya Ni Zhong
, Liangliang Kong
, Chao Wu
, Xin Wen
, Yuan Yuan
, Sheng Cao
, Changxiu Qu
, Xin Yang
, Chuan Cheng Yang
, Anjie Xia
, Zhenquan Hu
, Qianqian Zhang
, Yong Hao He
, Dao Lai Zhang
, Chao Zhang
, Gui Hua Hou
, Huanxiang Liu

Lizhe Zhu, Ping Fu, Shengyong Yang, Daniel M. Rosenbaum, Jin Peng Sun, Yang Du, Lei Zhang, Xiao Yu, Zhenhua Shao

Research output: Contribution to journal › Article › peer-review

128 Citations (Scopus)

Abstract

The cryo-EM structures of DRD1 coupled to its G protein, in complex with important agonists, elucidates the mechanism of G-protein-coupled selectivity and will facilitate future drug discovery and design.

Original language	English
Pages (from-to)	943-956.e18
Journal	Cell
Volume	184
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2021.01.028
Publication status	Published - 18 Feb 2021
Externally published	Yes

Keywords

DRD1-Gs complex
allosteric regulation
catecholamine
ccryo-EM
dopamine receptor
noncatechol
positive allosteric modulator
structure

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10.1016/j.cell.2021.01.028

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@article{7ccd78d462e3480caa236008ac025649,

title = "Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes",

abstract = "The cryo-EM structures of DRD1 coupled to its G protein, in complex with important agonists, elucidates the mechanism of G-protein-coupled selectivity and will facilitate future drug discovery and design.",

keywords = "DRD1-Gs complex, allosteric regulation, catecholamine, ccryo-EM, dopamine receptor, noncatechol, positive allosteric modulator, structure",

author = "Peng Xiao and Wei Yan and Lu Gou and Zhong, \{Ya Ni\} and Liangliang Kong and Chao Wu and Xin Wen and Yuan Yuan and Sheng Cao and Changxiu Qu and Xin Yang and Yang, \{Chuan Cheng\} and Anjie Xia and Zhenquan Hu and Qianqian Zhang and He, \{Yong Hao\} and Zhang, \{Dao Lai\} and Chao Zhang and Hou, \{Gui Hua\} and Huanxiang Liu and Lizhe Zhu and Ping Fu and Shengyong Yang and Rosenbaum, \{Daniel M.\} and Sun, \{Jin Peng\} and Yang Du and Lei Zhang and Xiao Yu and Zhenhua Shao",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2021",

month = feb,

day = "18",

doi = "10.1016/j.cell.2021.01.028",

language = "English",

volume = "184",

pages = "943--956.e18",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier BV",

number = "4",

}

Xiao, P, Yan, W, Gou, L, Zhong, YN, Kong, L, Wu, C, Wen, X, Yuan, Y, Cao, S, Qu, C, Yang, X, Yang, CC, Xia, A, Hu, Z, Zhang, Q, He, YH, Zhang, DL, Zhang, C, Hou, GH, Liu, H, Zhu, L, Fu, P, Yang, S, Rosenbaum, DM, Sun, JP, Du, Y, Zhang, L, Yu, X & Shao, Z 2021, 'Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes', Cell, vol. 184, no. 4, pp. 943-956.e18. https://doi.org/10.1016/j.cell.2021.01.028

TY - JOUR

T1 - Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes

AU - Xiao, Peng

AU - Yan, Wei

AU - Gou, Lu

AU - Zhong, Ya Ni

AU - Kong, Liangliang

AU - Wu, Chao

AU - Wen, Xin

AU - Yuan, Yuan

AU - Cao, Sheng

AU - Qu, Changxiu

AU - Yang, Xin

AU - Yang, Chuan Cheng

AU - Xia, Anjie

AU - Hu, Zhenquan

AU - Zhang, Qianqian

AU - He, Yong Hao

AU - Zhang, Dao Lai

AU - Zhang, Chao

AU - Hou, Gui Hua

AU - Liu, Huanxiang

AU - Zhu, Lizhe

AU - Fu, Ping

AU - Yang, Shengyong

AU - Rosenbaum, Daniel M.

AU - Sun, Jin Peng

AU - Du, Yang

AU - Zhang, Lei

AU - Yu, Xiao

AU - Shao, Zhenhua

PY - 2021/2/18

Y1 - 2021/2/18

N2 - The cryo-EM structures of DRD1 coupled to its G protein, in complex with important agonists, elucidates the mechanism of G-protein-coupled selectivity and will facilitate future drug discovery and design.

AB - The cryo-EM structures of DRD1 coupled to its G protein, in complex with important agonists, elucidates the mechanism of G-protein-coupled selectivity and will facilitate future drug discovery and design.

KW - DRD1-Gs complex

KW - allosteric regulation

KW - catecholamine

KW - ccryo-EM

KW - dopamine receptor

KW - noncatechol

KW - positive allosteric modulator

KW - structure

UR - https://www.scopus.com/pages/publications/85100630126

U2 - 10.1016/j.cell.2021.01.028

DO - 10.1016/j.cell.2021.01.028

M3 - Article

C2 - 33571432

AN - SCOPUS:85100630126

SN - 0092-8674

VL - 184

SP - 943-956.e18

JO - Cell

JF - Cell

IS - 4

ER -

Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes

Abstract

Keywords

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