Loureirin A Promotes Cell Differentiation and Suppresses Migration and Invasion of Melanoma Cells via WNT and AKT/mTOR Signaling Pathways

Zi Yi Xia, Ling Liu, Chiu Fai Kuok, Xue Li Wang, Dan Shi, Quan Ma, Xiao Yang Cheng, Guo Li Wang, Min Jing Li, Qiu Sheng Zheng, Xiao Na Liu, De Fang Li, Bo Han Li

Research output: Contribution to journalArticlepeer-review

Abstract

Resina Draconis is a traditional Chinese medicine, with the in-depth research, its medicinal value in anti-tumor has been revealed. Loureirin A is extracted from Resina Draconis, however, research on the antitumor efficacy of Loureirin A is rare. Herein, we investigated the function of Loureirin A in melanoma. Our research demonstrated that Loureirin A inhibited the proliferation of and caused G0/G1 cell cycle arrest in melanoma cells in a concentration-dependent manner. Further study showed that the melanin content and tyrosinase activity was enhanced after Loureirin A treatment, demonstrated that Loureirin A promoted melanoma cell differentiation, which was accompanied with the reduce of WNT signaling pathway. Meanwhile, we found that Loureirin A suppressed the migration and invasion of melanoma cells through the protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway. Taken together, this study demonstrated for the first time the anti-tumor effects of Loureirin A in melanoma cells, which provided a novel therapeutic strategy against melanoma.

Original languageEnglish
Pages (from-to)486-498
Number of pages13
JournalBiological and Pharmaceutical Bulletin
Volume47
Issue number2
DOIs
Publication statusPublished - Feb 2024

Keywords

  • cell differentiation
  • invasion
  • Loureirin A
  • melanoma
  • migration

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