Meloslines A and B, two novel indole alkaloids from Alstonia scholaris

Chiu Fai Kuok, Wen Cai Ye, Jian Zhang, Chun Lin Fan, Run Zhu Fan, Dong Mei Zhang, Xiao Qi Zhang, Wen Cai Ye

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


An unprecedented indole alkaloid melosline A (1), with 6/5/6/6 tetracyclic ring skeleton, together with a new alkaloid melosline B (2) and one known compound (3) were isolated from the leaves and twigs of Alstonia scholaris. The new structures were elucidated by comprehensive spectroscopic analysis. The absolute configuration of compound 1 was confirmed by comparison of experimental data with calculated electronic circular dichroism (ECD). Compound 1 exhibited moderate cytotoxicity against MCF-7 cancer cell lines.

Original languageEnglish
Pages (from-to)2740-2742
Number of pages3
JournalTetrahedron Letters
Issue number28
Publication statusPublished - 1 Jan 2017
Externally publishedYes


  • Absolute configuration
  • Alstonia scholaris
  • Cytotoxicity
  • Indole alkaloids


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