Meloslines A and B, two novel indole alkaloids from Alstonia scholaris

Chiu Fai Kuok; Wen Cai Ye; Jian Zhang; Chun Lin Fan; Run Zhu Fan; Dong Mei Zhang; Xiao Qi Zhang; Wen Cai Ye

doi:10.1016/j.tetlet.2017.05.094

Meloslines A and B, two novel indole alkaloids from Alstonia scholaris

Chiu Fai Kuok, Wen Cai Ye, Jian Zhang, Chun Lin Fan, Run Zhu Fan, Dong Mei Zhang, Xiao Qi Zhang, Wen Cai Ye

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

An unprecedented indole alkaloid melosline A (1), with 6/5/6/6 tetracyclic ring skeleton, together with a new alkaloid melosline B (2) and one known compound (3) were isolated from the leaves and twigs of Alstonia scholaris. The new structures were elucidated by comprehensive spectroscopic analysis. The absolute configuration of compound 1 was confirmed by comparison of experimental data with calculated electronic circular dichroism (ECD). Compound 1 exhibited moderate cytotoxicity against MCF-7 cancer cell lines.

Original language	English
Pages (from-to)	2740-2742
Number of pages	3
Journal	Tetrahedron Letters
Volume	58
Issue number	28
DOIs	https://doi.org/10.1016/j.tetlet.2017.05.094
Publication status	Published - 1 Jan 2017
Externally published	Yes

Keywords

Absolute configuration
Alstonia scholaris
Cytotoxicity
Indole alkaloids

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tetlet.2017.05.094

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title = "Meloslines A and B, two novel indole alkaloids from Alstonia scholaris",

abstract = "An unprecedented indole alkaloid melosline A (1), with 6/5/6/6 tetracyclic ring skeleton, together with a new alkaloid melosline B (2) and one known compound (3) were isolated from the leaves and twigs of Alstonia scholaris. The new structures were elucidated by comprehensive spectroscopic analysis. The absolute configuration of compound 1 was confirmed by comparison of experimental data with calculated electronic circular dichroism (ECD). Compound 1 exhibited moderate cytotoxicity against MCF-7 cancer cell lines.",

keywords = "Absolute configuration, Alstonia scholaris, Cytotoxicity, Indole alkaloids",

author = "Kuok, {Chiu Fai} and Ye, {Wen Cai} and Jian Zhang and Fan, {Chun Lin} and Fan, {Run Zhu} and Zhang, {Dong Mei} and Zhang, {Xiao Qi} and Ye, {Wen Cai}",

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doi = "10.1016/j.tetlet.2017.05.094",

language = "English",

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T1 - Meloslines A and B, two novel indole alkaloids from Alstonia scholaris

AU - Kuok, Chiu Fai

AU - Ye, Wen Cai

AU - Zhang, Jian

AU - Fan, Chun Lin

AU - Fan, Run Zhu

AU - Zhang, Dong Mei

AU - Zhang, Xiao Qi

AU - Ye, Wen Cai

PY - 2017/1/1

Y1 - 2017/1/1

N2 - An unprecedented indole alkaloid melosline A (1), with 6/5/6/6 tetracyclic ring skeleton, together with a new alkaloid melosline B (2) and one known compound (3) were isolated from the leaves and twigs of Alstonia scholaris. The new structures were elucidated by comprehensive spectroscopic analysis. The absolute configuration of compound 1 was confirmed by comparison of experimental data with calculated electronic circular dichroism (ECD). Compound 1 exhibited moderate cytotoxicity against MCF-7 cancer cell lines.

AB - An unprecedented indole alkaloid melosline A (1), with 6/5/6/6 tetracyclic ring skeleton, together with a new alkaloid melosline B (2) and one known compound (3) were isolated from the leaves and twigs of Alstonia scholaris. The new structures were elucidated by comprehensive spectroscopic analysis. The absolute configuration of compound 1 was confirmed by comparison of experimental data with calculated electronic circular dichroism (ECD). Compound 1 exhibited moderate cytotoxicity against MCF-7 cancer cell lines.

KW - Absolute configuration

KW - Alstonia scholaris

KW - Cytotoxicity

KW - Indole alkaloids

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U2 - 10.1016/j.tetlet.2017.05.094

DO - 10.1016/j.tetlet.2017.05.094

M3 - Article

AN - SCOPUS:85020455659

SN - 0040-4039

VL - 58

SP - 2740

EP - 2742

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 28

ER -

Meloslines A and B, two novel indole alkaloids from Alstonia scholaris

Abstract

Keywords

UN SDGs

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