Meloslines A and B, two novel indole alkaloids from Alstonia scholaris

Chiu Fai Kuok; Wen Cai Ye; Jian Zhang; Chun Lin Fan; Run Zhu Fan; Dong Mei Zhang; Xiao Qi Zhang; Wen Cai Ye

doi:10.1016/j.tetlet.2017.05.094

Meloslines A and B, two novel indole alkaloids from Alstonia scholaris

Chiu Fai Kuok
, Wen Cai Ye
, Jian Zhang
, Chun Lin Fan
, Run Zhu Fan
, Dong Mei Zhang
, Xiao Qi Zhang
, Wen Cai Ye

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

An unprecedented indole alkaloid melosline A (1), with 6/5/6/6 tetracyclic ring skeleton, together with a new alkaloid melosline B (2) and one known compound (3) were isolated from the leaves and twigs of Alstonia scholaris. The new structures were elucidated by comprehensive spectroscopic analysis. The absolute configuration of compound 1 was confirmed by comparison of experimental data with calculated electronic circular dichroism (ECD). Compound 1 exhibited moderate cytotoxicity against MCF-7 cancer cell lines.

Original language	English
Pages (from-to)	2740-2742
Number of pages	3
Journal	Tetrahedron Letters
Volume	58
Issue number	28
DOIs	https://doi.org/10.1016/j.tetlet.2017.05.094
Publication status	Published - 1 Jan 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Absolute configuration
Alstonia scholaris
Cytotoxicity
Indole alkaloids

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10.1016/j.tetlet.2017.05.094

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title = "Meloslines A and B, two novel indole alkaloids from Alstonia scholaris",

abstract = "An unprecedented indole alkaloid melosline A (1), with 6/5/6/6 tetracyclic ring skeleton, together with a new alkaloid melosline B (2) and one known compound (3) were isolated from the leaves and twigs of Alstonia scholaris. The new structures were elucidated by comprehensive spectroscopic analysis. The absolute configuration of compound 1 was confirmed by comparison of experimental data with calculated electronic circular dichroism (ECD). Compound 1 exhibited moderate cytotoxicity against MCF-7 cancer cell lines.",

keywords = "Absolute configuration, Alstonia scholaris, Cytotoxicity, Indole alkaloids",

author = "Kuok, \{Chiu Fai\} and Ye, \{Wen Cai\} and Jian Zhang and Fan, \{Chun Lin\} and Fan, \{Run Zhu\} and Zhang, \{Dong Mei\} and Zhang, \{Xiao Qi\} and Ye, \{Wen Cai\}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

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doi = "10.1016/j.tetlet.2017.05.094",

language = "English",

volume = "58",

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journal = "Tetrahedron Letters",

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T1 - Meloslines A and B, two novel indole alkaloids from Alstonia scholaris

AU - Kuok, Chiu Fai

AU - Ye, Wen Cai

AU - Zhang, Jian

AU - Fan, Chun Lin

AU - Fan, Run Zhu

AU - Zhang, Dong Mei

AU - Zhang, Xiao Qi

AU - Ye, Wen Cai

PY - 2017/1/1

Y1 - 2017/1/1

N2 - An unprecedented indole alkaloid melosline A (1), with 6/5/6/6 tetracyclic ring skeleton, together with a new alkaloid melosline B (2) and one known compound (3) were isolated from the leaves and twigs of Alstonia scholaris. The new structures were elucidated by comprehensive spectroscopic analysis. The absolute configuration of compound 1 was confirmed by comparison of experimental data with calculated electronic circular dichroism (ECD). Compound 1 exhibited moderate cytotoxicity against MCF-7 cancer cell lines.

AB - An unprecedented indole alkaloid melosline A (1), with 6/5/6/6 tetracyclic ring skeleton, together with a new alkaloid melosline B (2) and one known compound (3) were isolated from the leaves and twigs of Alstonia scholaris. The new structures were elucidated by comprehensive spectroscopic analysis. The absolute configuration of compound 1 was confirmed by comparison of experimental data with calculated electronic circular dichroism (ECD). Compound 1 exhibited moderate cytotoxicity against MCF-7 cancer cell lines.

KW - Absolute configuration

KW - Alstonia scholaris

KW - Cytotoxicity

KW - Indole alkaloids

UR - https://www.scopus.com/pages/publications/85020455659

U2 - 10.1016/j.tetlet.2017.05.094

DO - 10.1016/j.tetlet.2017.05.094

M3 - Article

AN - SCOPUS:85020455659

SN - 0040-4039

VL - 58

SP - 2740

EP - 2742

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 28

ER -

Meloslines A and B, two novel indole alkaloids from Alstonia scholaris

Abstract

UN SDGs

Keywords

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