Resveratrol cocrystals with enhanced solubility and tabletability

Zhengzheng Zhou, Wanying Li, Wei Jhe Sun, Tongbu Lu, Henry H.Y. Tong, Changquan Calvin Sun, Ying Zheng

Research output: Contribution to journalArticlepeer-review

90 Citations (Scopus)


Two new 1:1 cocrystals of resveratrol (RES) with 4-aminobenzamide (RES-4ABZ) and isoniazid (RES-ISN) were synthesized by liquid assisted grinding (LAG) and rapid solvent removal (RSR) methods using ethanol as solvent. Their physiochemical properties were characterized using PXRD, DSC, solid state and solution NMR, FT-IR, and HPLC. Pharmaceutically relevant properties, including tabletability, solubility, intrinsic dissolution rate, and hygroscopicity, were evaluated. Temperature-composition phase diagram for RES-ISN cocrystal system was constructed from DSC data. Both cocrystals show higher solubility than resveratrol over a broad range of pH. They are phase stable and non-hygroscopic even under high humidity conditions. Importantly, both cocrystals exhibit improved solubility and tabletability compared with RES, which make them more suitable candidates for tablet formulation development.

Original languageEnglish
Pages (from-to)391-399
Number of pages9
JournalInternational Journal of Pharmaceutics
Issue number1-2
Publication statusPublished - 25 Jul 2016


  • Cocrystal
  • Mechanical property
  • Resveratrol (RES)
  • Solubility
  • Tabletability


Dive into the research topics of 'Resveratrol cocrystals with enhanced solubility and tabletability'. Together they form a unique fingerprint.

Cite this