Synthetic K+ Channels Constructed by Rebuilding the Core Modules of Natural K+ Channels in an Artificial System

Pengyang Xin, Linqi Xu, Wenpei Dong, Linlin Mao, Jingjing Guo, Jingjing Bi, Shouwei Zhang, Yan Pei, Chang Po Chen

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Different types of natural K+ channels share similar core modules and cation permeability characteristics. In this study, we have developed novel artificial K+ channels by rebuilding the core modules of natural K+ channels in artificial systems. All the channels displayed high selectivity for K+ over Na+ and exhibited a selectivity sequence of K+≈Rb+ during the transport process, which is highly consistent with the cation permeability characteristics of natural K+ channels. More importantly, these artificial channels could be efficiently inserted into cell membranes and mediate the transmembrane transport of K+, disrupting the cellular K+ homeostasis and eventually triggering the apoptosis of cells. These findings demonstrate that, by rebuilding the core modules of natural K+ channels in artificial systems, the structures, transport behaviors, and physiological functions of natural K+ channels can be mimicked in synthetic channels.

Original languageEnglish
Article numbere202217859
JournalAngewandte Chemie - International Edition
Volume62
Issue number8
DOIs
Publication statusPublished - 13 Feb 2023

Keywords

  • Cyclodextrins
  • Ion Channels
  • Potassium
  • Supramolecular Chemistry
  • Transmembrane Transport

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