TRRG: Towards Truthful Radiology Report Generation With Cross-Modal Disease Clue Enhanced Large Language Models

Yuhao Wang, Yue Sun, Tao Tan, Chao Hao, Yawen Cui, Xinqi Su, Weichen Xie, Linlin Shen, Zitong Yu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The vision-language capabilities of multi-modal large language models have gained attention, but radiology report generation still faces challenges due to imbalanced data distribution and weak alignment between reports and radiographs. To address these issue, we propose TRRG, a stage-wise training framework for truthful radiology report generation. In the pre-training stage, contrastive learning enhances the visual encoder’s ability to capture fine-grained disease details. In the fine-tuning stage, our clue injection module improves disease perception by integrating robust zero-shot disease recognition. Finally, the cross-modal clue interaction module enables effective multi-granular fusion of visual and disease clue embeddings, significantly improving report generation and clinical effectiveness. Experiments on IU-Xray and MIMIC-CXR show that TRRG achieves state-of-the-art performance, enhancing disease perception and clinical utility.

Original languageEnglish
Title of host publicationMedical Image Computing and Computer Assisted Intervention, MICCAI 2025 - 28th International Conference, Proceedings
EditorsJames C. Gee, Jaesung Hong, Carole H. Sudre, Polina Golland, Daniel C. Alexander, Juan Eugenio Iglesias, Archana Venkataraman, Jong Hyo Kim
PublisherSpringer Science and Business Media Deutschland GmbH
Pages647-657
Number of pages11
ISBN (Print)9783032049803
DOIs
Publication statusPublished - 2026
Event28th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2025 - Daejeon, Korea, Republic of
Duration: 23 Sept 202527 Sept 2025

Publication series

NameLecture Notes in Computer Science
Volume15966 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference28th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2025
Country/TerritoryKorea, Republic of
CityDaejeon
Period23/09/2527/09/25

Keywords

  • Chest X-ray
  • Large Language Model
  • Radiology Report Generation

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