Understanding complex functional wiring patterns in major depressive disorder through brain functional connectome

Zhiyun Yang, Lingyu Jian, Hui Qiu, Chaoqing Zhang, Song Cheng, Junjun Ji, Ting Li, Yu Wang, Junfeng Li, Kefeng Li

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)


Brain function relies on efficient communications between distinct brain systems. The pathology of major depressive disorder (MDD) damages functional brain networks, resulting in cognitive impairment. Here, we reviewed the associations between brain functional connectome changes and MDD pathogenesis. We also highlighted the utility of brain functional connectome for differentiating MDD from other similar psychiatric disorders, predicting recurrence and suicide attempts in MDD, and evaluating treatment responses. Converging evidence has now linked aberrant brain functional network organization in MDD to the dysregulation of neurotransmitter signaling and neuroplasticity, providing insights into the neurobiological mechanisms of the disease and antidepressant efficacy. Widespread connectome dysfunctions in MDD patients include multiple, large-scale brain networks as well as local disturbances in brain circuits associated with negative and positive valence systems and cognitive functions. Although the clinical utility of the brain functional connectome remains to be realized, recent findings provide further promise that research in this area may lead to improved diagnosis, treatments, and clinical outcomes of MDD.

Original languageEnglish
Article number526
JournalTranslational Psychiatry
Issue number1
Publication statusPublished - Dec 2021
Externally publishedYes


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