硅橡胶导尿管表面季铵盐抗菌涂层制备与性能

Urinary catheters are crucial medical devices inserted through the urethra into the bladder to drain urine. However, as iatrogenic foreign bodies, they often cause mucosal damage and provide a pathway for bacterial invasion, leading to catheter-associated urinary tract infections (CAUTI). Surface functionalization to prevent bacterial colonization and proliferation on medical devices is a potential strategy to reduce CAUTI. In this study, the use of ultraviolet-initiated surface radical polymerization to directly modify the urinary catheter surface with a micron-scale quaternary ammonium hydrogel coating was reported for the first time. This coating significantly enhances the hydrophilicity of the urinary catheter surface and reduces surface friction. The quaternary ammonium groups in the coating disrupt bacterial cell membrane structures, endowing the urinary catheter surface with active antibacterial properties, achieving kill rates of 97.7% and 99.9% against Escherichia coli and Staphylococcus aureus, respectively. This surface-functionalized urinary catheter is expected to reduce tissue friction and bacterial colonization during catheterization, offering potential value in preventing mucosal damage and CAUTI.