2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6

Hongliang Duan; Jin Zheng; Qinglin Lai; Zheng Liu; Guanghui Tian; Zhen Wang; Jianfeng Li; Jingshan Shen

doi:10.1016/j.bmcl.2009.03.125

2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6

Hongliang Duan
, Jin Zheng
, Qinglin Lai
, Zheng Liu
, Guanghui Tian
, Zhen Wang
, Jianfeng Li
, Jingshan Shen

研究成果: Article › 同行評審

24 引文斯高帕斯（Scopus）

摘要

In our efforts to minimize the side effects associated with low selectivity against the other PDE isozymes, a novel class of 2-phenylquinazolin-4(3H)-one derivatives were designed and prepared as potent PDE5 inhibitors with high selectivity against PDE6. The syntheses and SAR studies of such molecules were reported.

原文	English
頁（從 - 到）	2777-2779
頁數	3
期刊	Bioorganic and Medicinal Chemistry Letters
卷	19
發行號	10
DOIs	https://doi.org/10.1016/j.bmcl.2009.03.125
出版狀態	Published - 15 5月 2009
對外發佈	是

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10.1016/j.bmcl.2009.03.125

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abstract = "In our efforts to minimize the side effects associated with low selectivity against the other PDE isozymes, a novel class of 2-phenylquinazolin-4(3H)-one derivatives were designed and prepared as potent PDE5 inhibitors with high selectivity against PDE6. The syntheses and SAR studies of such molecules were reported.",

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T1 - 2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6

AU - Duan, Hongliang

AU - Zheng, Jin

AU - Lai, Qinglin

AU - Liu, Zheng

AU - Tian, Guanghui

AU - Wang, Zhen

AU - Li, Jianfeng

AU - Shen, Jingshan

PY - 2009/5/15

Y1 - 2009/5/15

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AB - In our efforts to minimize the side effects associated with low selectivity against the other PDE isozymes, a novel class of 2-phenylquinazolin-4(3H)-one derivatives were designed and prepared as potent PDE5 inhibitors with high selectivity against PDE6. The syntheses and SAR studies of such molecules were reported.

KW - 2-Phenylquinazolin-4(3H)-one

KW - Erectile dysfunction

KW - PDE5 Inhibitor

KW - Selectivity versus PDE6

KW - Sildenafil

UR - https://www.scopus.com/pages/publications/65449165278

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 10

ER -

2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6

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