A unimolecular channel formed by dual helical peptide modified pillar[5]arene: Correlating transmembrane transport properties with antimicrobial activity and haemolytic toxicity

Pengyang Xin, Yonghui Sun, Huiyuan Kong, Yaodong Wang, Si Tan, Jingjing Guo, Tao Jiang, Wenpei Dong, Chang Po Chen

研究成果: Article同行評審

20 引文 斯高帕斯(Scopus)

摘要

Five unimolecular channels with different lengths are presented. The varying length of these channels has significant impact on their transmembrane transport properties, which are directly correlated with their antimicrobial activity and inversely correlated with their haemolytic toxicity. By further structural optimization, these new channels could reach high antimicrobial activity and very low haemolytic toxicity, with the potential to serve as systemic antibiotics.

原文English
頁(從 - 到)11492-11495
頁數4
期刊Chemical Communications
53
發行號83
DOIs
出版狀態Published - 2017
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