Classification of breast lesions in automated 3D breast ultrasound

Tao Tan, Henkjan Huisman, Bram Platel, Andre Grivegnee, Roel Mus, Nico Karssemeijer

研究成果: Conference contribution同行評審

8 引文 斯高帕斯(Scopus)


In this paper we investigated classification of malignant and benign lesions in automated 3D breast ultrasound (ABUS). As a new imaging modality, ABUS overcomes the drawbacks of 2D hand-held ultrasound (US) such as its operator dependence and limited capability in visualizing the breast in 3D. The classification method we present includes a 3D lesion segmentation stage based on dynamic programming, which effectively deals with limited visibility of lesion boundaries due to shadowing and speckle. A novel aspect of ABUS imaging, in which the breast is compressed by means of a dedicated membrane, is the presence of spiculation in coronal planes perpendicular to the transducer. Spiculation patterns, or architectural distortion, are characteristic for malignant lesions. Therefore, we compute a spiculation measure in coronal planes and combine this with more traditional US features related to lesion shape, margin, posterior acoustic behavior, and echo pattern. However, in our work the latter features are defined in 3D. Classification experiments were performed with a dataset of 40 lesions including 20 cancers. Linear discriminant analysis (LDA) was used in combination with leaveone- patient-out and feature selection in each training cycle. We found that spiculation and margin contrast were the most discriminative features and that these features were most often chosen during feature selection. An Az value of 0.86 was obtained by merging all features, while an Az value of 0.91 was obtained by feature selection.

主出版物標題Medical Imaging 2011
主出版物子標題Computer-Aided Diagnosis
出版狀態Published - 2011
事件Medical Imaging 2011: Computer-Aided Diagnosis - Lake Buena Vista, FL, United States
持續時間: 15 2月 201117 2月 2011


名字Progress in Biomedical Optics and Imaging - Proceedings of SPIE


ConferenceMedical Imaging 2011: Computer-Aided Diagnosis
國家/地區United States
城市Lake Buena Vista, FL


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