@article{49ebccdfa3ac4bcd97b9f925e8220bd9,
title = "Engineering of pharmaceutical materials: An industrial perspective",
abstract = "Crystal engineering provides a rational approach to solving formulation, processing and product performance problems. This review discusses how the concept of crystal engineering can be judiciously utilized to manipulate the solid-state properties of drugs and excipients for successful pharmaceutical formulation and process development. Existing and emerging manufacturing as well as co-processing technologies being applied in the pharmaceutical industry are also presented together with selected examples of crystal form design, crystal form selection and crystal modifications for illustration purposes.",
keywords = "Crystal engineering, Crystallization, Formulation, Particle size, Pharmaceutical manufacturing, Polymorphism, Preformulation, Selection of salt forms",
author = "Kwok Chow and Tong, {Henry H.Y.} and Susan Lum and Chow, {Albert H.L.}",
note = "Funding Information: This article is dedicated to the late Professor David J. W. Grant, an inspirational leader and an excellent mentor in the field of crystal engineering. Financial support from the Macao Polytechnic Institute (Project No. RP/ESS 10/2005) for Henry H. T. Tong is gratefully acknowledged. ",
year = "2008",
month = aug,
doi = "10.1002/jps.21212",
language = "English",
volume = "97",
pages = "2855--2877",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "John Wiley & Sons Inc.",
number = "8",
}