@article{30f1c9b5424449e6953cf92acda35dd2,
title = "Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR",
abstract = "Epigenetic differences may help to distinguish between PTSD cases and trauma-exposed controls. Here, we describe the results of the largest DNA methylation meta-analysis of PTSD to date. Ten cohorts, military and civilian, contribute blood-derived DNA methylation data from 1,896 PTSD cases and trauma-exposed controls. Four CpG sites within the aryl-hydrocarbon receptor repressor (AHRR) associate with PTSD after adjustment for multiple comparisons, with lower DNA methylation in PTSD cases relative to controls. Although AHRR methylation is known to associate with smoking, the AHRR association with PTSD is most pronounced in non-smokers, suggesting the result was independent of smoking status. Evaluation of metabolomics data reveals that AHRR methylation associated with kynurenine levels, which are lower among subjects with PTSD. This study supports epigenetic differences in those with PTSD and suggests a role for decreased kynurenine as a contributor to immune dysregulation in PTSD.",
author = "{INTRuST Clinical Consortium} and {VA Mid-Atlantic MIRECC Workgroup} and {PGC PTSD Epigenetics Workgroup} and Smith, {Alicia K.} and Andrew Ratanatharathorn and Maihofer, {Adam X.} and Naviaux, {Robert K.} and Aiello, {Allison E.} and Amstadter, {Ananda B.} and Ashley-Koch, {Allison E.} and Baker, {Dewleen G.} and Beckham, {Jean C.} and Boks, {Marco P.} and Evelyn Bromet and Michelle Dennis and Sandro Galea and Garrett, {Melanie E.} and Elbert Geuze and Guia Guffanti and Hauser, {Michael A.} and Seyma Katrinli and Varun Kilaru and Kessler, {Ronald C.} and Kimbrel, {Nathan A.} and Koenen, {Karestan C.} and Kuan, {Pei Fen} and Kefeng Li and Logue, {Mark W.} and Adriana Lori and Luft, {Benjamin J.} and Miller, {Mark W.} and Naviaux, {Jane C.} and Nugent, {Nicole R.} and Xuejun Qin and Ressler, {Kerry J.} and Risbrough, {Victoria B.} and Rutten, {Bart P.F.} and Stein, {Murray B.} and Ursano, {Robert J.} and Eric Vermetten and Vinkers, {Christiaan H.} and Lin Wang and Youssef, {Nagy A.} and Christine Marx and Gerry Grant and Murray Stein and Qin, {Xue Jun} and Sonia Jain and McAllister, {Thomas W.} and Ross Zafonte and Ariel Lang and Raul Coimbra and Norberto Andaluz",
note = "Publisher Copyright: {\textcopyright} 2020, The Author(s).",
year = "2020",
month = dec,
day = "1",
doi = "10.1038/s41467-020-19615-x",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}