TY - JOUR
T1 - Expression and clinical significance of KISS-1 and GPR54 mRNA in endometrial carcinoma
AU - Jiang, Tao
AU - Zhang, Shu lan
AU - Lin, Bei
AU - Meng, Li rong
AU - Gao, Hong
PY - 2005/4
Y1 - 2005/4
N2 - OBJECTIVE: To investigate the expression and clinical significance of KISS-1 mRNA and GPR54 mRNA in endometrial carcinoma. METHODS: The expression of KISS-1 mRNA and GPR54 mRNA in 32 patients with endometrial carcinoma, 10 patients with endometrial intraepithelial neoplasia (EIN) and 12 patients with normal endometrium was detected by reverse transcriptase polymerase chain reaction (RT-PCR). RESULTS: The positive rate of KISS-1 mRNA in endometrial carcinoma, EIN and normal endometrium was 37.5%, 80.0% and 83.3% respectively (endometrial carcinoma vs EIN or normal endometrium, P < 0.05). The expression of KISS-1mRNA in patients with endometrial carcinoma was correlated with its clinical stage, myometrial invasion and lymph node metastasis (P < 0.05). In endometrial carcinoma, the more advanced clinical stage, the lower expression of KISS-1 mRNA was detected. The positive rate of GPR54 mRNA in endometrial carcinoma, EIN and normal endometrium was 78.1%, 70.0% and 66.7% respectively, with no significant statistical difference (P > 0.05). It was not correlated with the clinical stage, histology grade, myometrial invasion or lymph node metastasis (P > 0.05). CONCLUSION: The interaction of KISS-1 and GPR54 may play an important role in inhibiting the invasion and metastasis of endometrial carcinoma.
AB - OBJECTIVE: To investigate the expression and clinical significance of KISS-1 mRNA and GPR54 mRNA in endometrial carcinoma. METHODS: The expression of KISS-1 mRNA and GPR54 mRNA in 32 patients with endometrial carcinoma, 10 patients with endometrial intraepithelial neoplasia (EIN) and 12 patients with normal endometrium was detected by reverse transcriptase polymerase chain reaction (RT-PCR). RESULTS: The positive rate of KISS-1 mRNA in endometrial carcinoma, EIN and normal endometrium was 37.5%, 80.0% and 83.3% respectively (endometrial carcinoma vs EIN or normal endometrium, P < 0.05). The expression of KISS-1mRNA in patients with endometrial carcinoma was correlated with its clinical stage, myometrial invasion and lymph node metastasis (P < 0.05). In endometrial carcinoma, the more advanced clinical stage, the lower expression of KISS-1 mRNA was detected. The positive rate of GPR54 mRNA in endometrial carcinoma, EIN and normal endometrium was 78.1%, 70.0% and 66.7% respectively, with no significant statistical difference (P > 0.05). It was not correlated with the clinical stage, histology grade, myometrial invasion or lymph node metastasis (P > 0.05). CONCLUSION: The interaction of KISS-1 and GPR54 may play an important role in inhibiting the invasion and metastasis of endometrial carcinoma.
UR - http://www.scopus.com/inward/record.url?scp=33750090751&partnerID=8YFLogxK
M3 - Article
C2 - 15949424
AN - SCOPUS:33750090751
SN - 0253-3766
VL - 27
SP - 229
EP - 231
JO - Chinese Journal of Oncology
JF - Chinese Journal of Oncology
IS - 4
ER -