Glycerol is Released from a New Path in MGL Lipase Catalytic Process

Dongming Lan, Shu Li, Wei Tang, Zexin Zhao, Mupeng Luo, Shuguang Yuan, Jun Xu, Yonghua Wang

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)


Traditionally, it is believed that the substrate and products of a monoacylglycerol lipase (MGL) share the same path to enter and exit the catalytic site. Glycerol (a product of MGL), however, was recently hypothesized to be released through a different path. In order to improve the catalytic efficacy and thermo-stability of MGL, it is important to articulate the pathways of a MGL products releasing. In this study, with structure biological approaches, biochemical experiments, and in silico methods, we prove that glycerol is released from a different path in the catalytic site indeed. The fatty acid (another product of MGL) does share the same binding path with the substrate. This discovery paves a new road to design MGL inhibitors or optimize MGL catalytic efficacy.

期刊Journal of Chemical Information and Modeling
出版狀態Accepted/In press - 2021


深入研究「Glycerol is Released from a New Path in MGL Lipase Catalytic Process」主題。共同形成了獨特的指紋。