miR-124 and VAMP3 Act Antagonistically in Human Neuroblastoma

Xiaoxiao Zhang, Chengyong Yang, Zhen Meng, Huanhuan Zhong, Xutian Hou, Fenfen Wang, Yiping Lu, Jingjing Guo, Yan Zeng

研究成果: Article同行評審

3 引文 斯高帕斯(Scopus)

摘要

Neuroblastoma (NB) is the most common extracranial solid tumor that affects developing nerve cells in the fetus, infants, and children. miR-124 is a microRNA (miRNA) enriched in neuronal tissues, and VAMP3 (vesicle-associated membrane protein 3) has been reported to be an miR-124 target, although the relationship between NB and miR-124 or VAMP3 is unknown. Our current work identified that miR-124 levels are high in NB cases and that elevated miR-124 correlates with worse NB outcomes. Conversely, depressed VAMP3 correlates with worse NB outcomes. To investigate the mechanisms by which miR-124 and VAMP3 regulate NB, we altered miR-124 or VAMP3 expression in human NB cells and observed that increased miR-124 and reduced VAMP3 stimulated cell proliferation and suppressed apoptosis, while increased VAMP3 had the opposite effects. Genome-wide mRNA expression analyses identified gene and pathway changes which might explain the NB cell phenotypes. Together, our studies suggest that miR-124 and VAMP3 could be potential new markers of NB and targets of NB treatments.

原文English
文章編號14877
期刊International Journal of Molecular Sciences
24
發行號19
DOIs
出版狀態Published - 10月 2023

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