Unexpected Discovery: Based on Data Mining, Rheumatoid Arthritis Surprisingly Reduces the Risk of Developing Hodgkin’s Lymphoma

Yong De Cai, Hong Da Zhou, Eng Xin Xie, Jian Fang Zhang, Tao Tan, Hui Xie

研究成果: Conference contribution同行評審

摘要

To investigate the potential correlation between rheumatoid arthritis (RA) and the predisposition to Hodgkin’s lymphoma (HL), we conducted a comprehensive analysis leveraging Mendelian randomization (MR) techniques and genome-wide association studies (GWAS) data. The study focused on the European population, utilizing comprehensive genome sequences from individuals with RA and malignant lymphoma. To identify single nucleotide polymorphisms (SNPs) strongly associated with RA in the European cohort, we employed the inverse variance weighted (IVW) analysis as a robust genetic tool. Furthermore, we utilized various analytical methods, including IVW, weighted median analysis, weighted mode, and MR-Egger regression, to delve into the potential association between RA and the risk of malignant lymphoma in this population. Our findings, obtained through rigorous statistical analysis, revealed a significant causal relationship. Specifically, the IVW analysis (OR = 0.789, 95% CI: 0.6588–0.946, P = 0.009), weighted median analysis (OR = 0.725, 95% CI: 0.607–0.864, P = 0.0001), and weighted mode analysis (OR = 0.709, 95% CI: 0.600–0.838, P = 0.002) consistently indicated that RA decreases the risk of developing malignant lymphoma. Importantly, our results did not indicate any evidence of horizontal pleiotropy (Egger intercept = 0.04, P = 0.576) or heterogeneity (P = 0.056), suggesting the robustness and reliability of our findings. Further sensitivity analysis and statistical evaluations did not yield any notable exceptions or deviations from our initial conclusions. In summary, our study provides compelling evidence that, in the European population, rheumatoid arthritis may serve as a protective factor, reducing the risk of developing Hodgkin’s lymphoma.

原文English
主出版物標題Proceedings of International Conference on Image, Vision and Intelligent Systems, ICIVIS 2024 - Volume II
編輯Peng You, Yuhui Zheng
發行者Springer Science and Business Media Deutschland GmbH
頁面267-285
頁數19
ISBN(列印)9789819625277
DOIs
出版狀態Published - 2025
事件International Conference on Image, Vision and Intelligent Systems, ICIVIS 2024 - Xining, China
持續時間: 16 6月 202417 6月 2024

出版系列

名字Lecture Notes in Electrical Engineering
1362
ISSN(列印)1876-1100
ISSN(電子)1876-1119

Conference

ConferenceInternational Conference on Image, Vision and Intelligent Systems, ICIVIS 2024
國家/地區China
城市Xining
期間16/06/2417/06/24

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